ReviewExtremophiles : life under extreme conditions2004
Small heat shock proteins from extremophiles: a review.
Review in Extremophiles : life under extreme conditions, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 97 citations in OpenAlex.
- Elucidating the role of compatible solutes in growth protection and amelioration of oxidative stress in the thermophilic cyanobacterium Mastigocladus sp. TA-8 during temperature shifts.Extremophiles : life under extreme conditions · 2025Article
- Review
- RNA-Seq Insight into the Impact and Mechanisms of Methyl Donor and Glycine Betaine Osmoprotectant on Polyketide Secondary Metabolism inJournal of fungi (Basel, Switzerland) · 2025Article
- Extremophiles and Extremophilic Behaviour-New Insights and Perspectives.Life (Basel, Switzerland) · 2024Review
- Untangling the adaptive strategies of thermophilic bacterium Anoxybacillus rupiensis TPH1 under low temperature.Extremophiles : life under extreme conditions · 2024Article
- Integrating multi-platform assembly to recover MAGs from hot spring biofilms: insights into microbial diversity, biofilm formation, and carbohydrate degradation.Environmental microbiome · 2024Article
- Heat Shock Response and Heat Shock Proteins: Current Understanding and Future Opportunities in Human Diseases.International journal of molecular sciences · 2024Review
- Small Heat Shock Protein (sHsp22.98) fromViruses · 2023Article
- Tardigrade small heat shock proteins can limit desiccation-induced protein aggregation.Communications biology · 2023Article
- Minimal Yet Powerful: The Role of Archaeal Small Heat Shock Proteins in Maintaining Protein Homeostasis.Frontiers in molecular biosciences · 2022Review
- Multiple nanocages of a cyanophage small heat shock protein with icosahedral and octahedral symmetries.Scientific reports · 2021Article
- Redox-Sensitive VDAC: A Possible Function as an Environmental Stress Sensor Revealed by Bioinformatic Analysis.Frontiers in physiology · 2021Article
- Defining heat shock response for the thermoacidophilic model crenarchaeon Sulfolobus acidocaldarius.Extremophiles : life under extreme conditions · 2020Article
- Mechanisms of Desiccation Tolerance: Themes and Variations in Brine Shrimp, Roundworms, and Tardigrades.Frontiers in physiology · 2020Review
- Computational genome-wide identification of heat shock protein genes in the bovine genome.F1000Research · 2018Article
- Structural and mechanistic characterization of an archaeal-like chaperonin from a thermophilic bacterium.Nature communications · 2017Article
- Expression of CeHSP17 Protein in Response to Heat Shock and Heavy Metal Ions.Journal of nematology · 2017Article
- Crystal structure of a small heat-shock protein from Xylella fastidiosa reveals a distinct high-order structure.Acta crystallographica. Section F, Structural biology communications · 2017Article
- Impact of trehalose transporter knockdown on Anopheles gambiae stress adaptation and susceptibility to Plasmodium falciparum infection.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Transcriptome profiling of peanut gynophores revealed global reprogramming of gene expression during early pod development in darkness.BMC genomics · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many microorganisms from extreme environments have been well characterized, and increasing access to genomic sequence data has recently allowed the analysis of the protein families related to stress responses. Heat shock proteins appear to be ubiquitous in extremophiles. In this review, we focus on the family of small heat shock proteins (sHSPs) from extremophiles, which are alpha-crystallin homologues. Like the alpha-crystallin eye lens proteins, sHSPs act as molecular chaperones and prevent aggregation of denatured proteins under heat and desiccation stress. Many putative sHSP homologues have been identified in the genomic sequences of all classes of extremophiles. Current studies of shsp gene expression have revealed mechanisms of regulation and activity distinct from other known hsp gene regulation systems. Biochemical studies on sHSPs are limited to thermophilic and hyperthermophilic organisms, and the only two available crystal structures of sHSPs from Methanocaldococcus jannaschii, a hyperthermophilic archaeon and a mesophilic eukaryote, have contributed significantly to an understanding of the mechanisms of action of sHSPs, although many aspects remain unclear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.