ArticleNaunyn-Schmiedeberg's archives of pharmacology2004
Differential effects of acute cannabinoid drug treatment, mediated by CB1 receptors, on the in vivo activity of tyrosine and tryptophan hydroxylase in the rat brain.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Uncovering the Metabolic Footprint of New Psychoactive Substances by Metabolomics: A Systematic Review.Molecules (Basel, Switzerland) · 2025Pooled it
- Intermittent marijuana use is associated with improved retention in naltrexone treatment for opiate-dependence.The American journal on addictionsTrial
- Metabolomic profiling of cannabis use and cannabis intoxication in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Cannabinoids and monoaminergic system: implications for learning and memory.Frontiers in neuroscience · 2024Review
- The neuropharmacology of cannabinoid receptor ligands in central signaling pathways.The European journal of neuroscience · 2022Review
- Molecular Targets of Cannabinoids Associated with Depression.Current medicinal chemistry · 2022Review
- Inhaled Cannabis Suppresses Chemotherapy-Induced Neuropathic Nociception by Decoupling the Raphe Nucleus: A Functional Imaging Study in Rats.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Complex Patterns of Cannabinoid Alkyl Side-Chain Inheritance in Cannabis.Scientific reports · 2019Article
- Interactions of endocannabinoid virodhamine and related analogs with human monoamine oxidase-A and -B.Biochemical pharmacology · 2018Article
- Endocannabinoid signaling in the etiology and treatment of major depressive illness.Current pharmaceutical design · 2014Review
- Ventral striatal dopamine synthesis capacity predicts financial extravagance in Parkinson's disease.Frontiers in psychology · 2013Article
- Stress-induced sensitization of cortical adrenergic receptors following a history of cannabinoid exposure.Experimental neurology · 2012Article
- Cannabinoid modulation of noradrenergic circuits: implications for psychiatric disorders.Progress in neuro-psychopharmacology & biological psychiatry · 2012Review
- Neural Circuit in the Dorsal Raphe Nucleus Responsible for Cannabinoid-Mediated Increases in 5-HT Efflux in the Nucleus Accumbens of the Rat Brain.ISRN pharmacology · 2012Article
- Reflection impulsivity in adolescent cannabis users: a comparison with alcohol-using and non-substance-using adolescents.Psychopharmacology · 2012Article
- Article
- Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats.Neuropharmacology · 2011Article
- Genetic deletion of fatty acid amide hydrolase alters emotional behavior and serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- Inhibition of monoamine oxidase activity by cannabinoids.Naunyn-Schmiedeberg's archives of pharmacology · 2010Article
- Effect of the CB(1) receptor antagonists rimonabant and AM251 on the firing rate of dorsal raphe nucleus neurons in rat brain slices.British journal of pharmacology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The acute effects of cannabinoid drugs on the synthesis of noradrenaline, dopamine, and serotonin (5-HT) were assessed, simultaneously, using the accumulation of 3,4-dihydroxyphenylalanine (dopa) and 5-hydroxytryptophan (5-HTP) after decarboxylase inhibition as a measure of the rate of tyrosine and tryptophan hydroxylation in the rat brain in vivo. Treatment (1 h, i.p.) with Delta(9)-tetrahydrocannabinol (THC, 5, 10, and 20 mg/kg) and the cannabinoid receptor agonist WIN 55,212-2 (WIN, 2 and 4 mg/kg) increased dopa/noradrenaline synthesis (40-70%) in various brain regions enriched in this neurotransmitter (e.g., cerebral cortex, hippocampus, hypothalamus). In most brain regions, the content of noradrenaline was reduced by cannabinoid drugs (27-66%). For the effects of WIN (2 and 4 mg/kg), an inverse correlation ( r=-0.61, P=0.036) was obtained between the accumulation of dopa and the content of noradrenaline in the hypothalamus. The stimulatory effect on dopa accumulation induced by THC was antagonized by the selective CB(1) receptor antagonists SR141716A and AM 281 (10 mg/kg). In contrast, THC and WIN decreased the synthesis of dopa/dopamine in the corpus striatum (16-37%) and that of 5-HTP/5-HT (20-35%) in brain regions enriched in 5-HT (e.g., cerebral cortex and hippocampus). These inhibitory effects of THC and WIN were also antagonized by AM 281 and/or SR141716A. THC did not alter the content of 5-HT or dopamine in the brain. The effects may be related to the activation of presynaptic inhibitory cannabinoid CB(1) receptors located on the neurones themselves (serotonin) and on facilitatory (dopamine) and inhibitory interneurones (noradrenaline).
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