ArticleExperimental brain research2004
Mean sustained pain levels are linked to hemispherical side-to-side differences of primary somatosensory cortex in the complex regional pain syndrome I.
Article in Experimental brain research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 168 citations in OpenAlex.
- [Mirror therapy for phantom limb pain--a systematic review].Wiener klinische Wochenschrift · 2009Pooled it
- Trial
- Reduced somatosensory evoked potentials and paired-pulse inhibition in the primary somatosensory cortex of athletes with chronic pain.European journal of applied physiology · 2023Article
- Atypical influence of biomechanical knowledge in Complex Regional Pain Syndrome-towards a different perspective on body representation.Scientific reports · 2023Article
- VR for Pain Relief.Current topics in behavioral neurosciences · 2023Article
- Predictors of Self-Reported Neglect-like Symptoms and Involuntary Movements in Complex Regional Pain Syndrome Compared to Other Chronic Limb Pain Conditions.Pain medicine (Malden, Mass.) · 2021Article
- Neuroanatomical correlates of poststroke complex regional pain syndrome: a voxel-based lesion symptom-mapping study.Scientific reports · 2021Article
- Article
- Complex Regional Pain Syndrome. A Comprehensive Review on Neuroplastic Changes Supporting the Use of Non-invasive Neurostimulation in Clinical Settings.Frontiers in pain research (Lausanne, Switzerland) · 2021Review
- Graded motor imagery modifies movement pain, cortical excitability and sensorimotor function in complex regional pain syndrome.Brain communications · 2021Article
- Peripherally Induced Reconditioning of the Central Nervous System: A Proposed Mechanistic Theory for Sustained Relief of Chronic Pain with Percutaneous Peripheral Nerve Stimulation.Journal of pain research · 2021Review
- Implications of the putamen in pain and motor deficits in complex regional pain syndrome.Pain · 2020Article
- Neuropsychological Changes in Complex Regional Pain Syndrome (CRPS).Behavioural neurology · 2020Review
- Fine-Grained Mapping of Cortical Somatotopies in Chronic Complex Regional Pain Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The effect of experimental pain on short-interval intracortical inhibition with multi-locus transcranial magnetic stimulation.Experimental brain research · 2019Article
- Role of Rehabilitation in Neural Plasticity.Open access Macedonian journal of medical sciences · 2019Review
- Distinguishing between nociceptive and neuropathic components in chronic low back pain using behavioural evaluation and sensory examination.Musculoskeletal science & practice · 2017Article
- Somatosensory Misrepresentation Associated with Chronic Pain: Spatiotemporal Correlates of Sensory Perception in a Patient following a Complex Regional Pain Syndrome Spread.Frontiers in neurology · 2017Article
- [Maladaptive plasticity in chronic and neuropathic pain].Schmerz (Berlin, Germany) · 2016Review
- Neurocognitive and Neuroplastic Mechanisms of Novel Clinical Signs in CRPS.Frontiers in human neuroscience · 2016Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic back pain as well as phantom-limb pain is characterized by a close relationship between the amount of cortical reorganization and the magnitude of pain. In patients with positively assessed complex regional pain syndrome type I (CRPS I), we found a positive correlation between representational changes of primary somatosensory cortex (SI) and mean sustained pain levels. We investigated seven right-handed patients with CRPS I of one upper limb by means of somatosensory evoked potential (SSEP) mapping. Cortical representation of the CRPS-affected hand was significantly smaller than that of the contralateral healthy hand, giving rise to a substantial side difference. Subjective pain levels experienced over the last 4 weeks were estimated according to the visual analogue scale (VAS). Individual expansion of hand representation contralateral to the CRPS-affected limb was significantly correlated with mean pain intensity. Accordingly, low pain levels were linked to small representational side-to-side differences, while subjects with a distinctive hemispherical asymmetry reported the highest pain levels. Follow-up studies using functional imaging methods might be instrumental in providing a better understanding of this issue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.