ArticleOncogene2004
The exonuclease ISG20 is directly induced by synthetic dsRNA via NF-kappaB and IRF1 activation.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Exonuclease ISG20 inhibits human cytomegalovirus replication by inducing an innate immune defense signature.PLoS pathogens · 2026Article
- ISG20: The multifaceted 'molecular star' in cancer research (Review).Oncology reports · 2025Review
- A Novel Approach of Antiviral Drugs Targeting Viral Genomes.Microorganisms · 2022Review
- Identification and Verification of Necroptosis-Related Gene Signature With Prognosis and Tumor Immune Microenvironment in Ovarian Cancer.Frontiers in immunology · 2022Article
- Article
- CD34+ derived macrophage and dendritic cells display differential responses to paraquat.Toxicology in vitro : an international journal published in association with BIBRA · 2021Article
- High expression of ISG20 predicts a poor prognosis in acute myeloid leukemia.Cancer biomarkers : section A of Disease markers · 2021Article
- A new transcription factor ATG10S activates IFNL2 transcription by binding at an IRF1 site in HepG2 cells.Autophagy · 2020Article
- Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development.The Journal of pathology · 2020Article
- Interferon-stimulated gene 20 (ISG20) selectively degrades N6-methyladenosine modified Hepatitis B Virus transcripts.PLoS pathogens · 2020Article
- ISG20 serves as a potential biomarker and drives tumor progression in clear cell renal cell carcinoma.Aging · 2020Article
- ISG20 is overexpressed in clinically relevant radioresistant oral cancer cells.International journal of clinical and experimental pathology · 2020Article
- Induction of interferon-stimulated genes and cellular stress pathways by morpholinos in zebrafish.Developmental biology · 2019Article
- Interferon-stimulated gene 20 kDa protein serum levels and clinical outcome of hepatitis B virus-related liver diseases.Oncotarget · 2018Article
- Stimulation of Interferon-Stimulated Gene 20 by Thyroid Hormone Enhances Angiogenesis in Liver Cancer.Neoplasia (New York, N.Y.) · 2018Article
- Interferon-stimulated gene 20-kDa protein (ISG20) in infection and disease: Review and outlook.Intractable & rare diseases research · 2017Review
- Novel RNA Duplex Locks HIV-1 in a Latent State via Chromatin-mediated Transcriptional Silencing.Molecular therapy. Nucleic acids · 2015Article
- Review
- Antiviral and immunoregulatory activities of IFN-gamma depend on constitutively expressed IL-1alpha.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Suppression of proinflammatory signal transduction and gene expression by the dual nucleic acid binding domains of the vaccinia virus E3L proteins.Journal of virology · 2006Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many interferon (IFN)-stimulated genes are also induced by double-stranded RNA (dsRNA), a component closely associated with the IFN system in the context of virus-host interactions. Recently, we demonstrated that the IFN-induced 3' --> 5' exonuclease ISG20 possesses antiviral activities against RNA viruses. Here we show that ISG20 induction by synthetic dsRNA (pIpC) is stronger and faster than its induction by IFN. Two families of transcription factors are implicated in the transcriptional activation of ISG20 by dsRNA. Initially, the NF-kappaB factors p50 and p65 bind and activate the kappaB element of the Isg20 promoter. This is followed by IRF1 binding to the ISRE. As pIpC often induces protein movements in the cells, we questioned whether it could influence ISG20 localization. Interestingly and contrary to IFN, dsRNA induces a nuclear matrix enrichment of the ISG20 protein. dsRNA induction of ISG20 via NF-kappaB and its antiviral activity led us to suggest that ISG20 could participate in the cellular response to virus infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.