ArticleOncogene2004
Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- A multi-omics analysis identifies molecular features associated with fertility in heifers (Bos taurus).Scientific reports · 2023Article
- Novel Functional Features of cGMP Substrate Proteins IRAG1 and IRAG2.International journal of molecular sciences · 2023Review
- Discriminative pattern discovery for the characterization of different network populations.Bioinformatics (Oxford, England) · 2023Article
- Comparative genomic analyses of multiple backcross mouse populations suggest SGCG as a novel potential obesity-modifier gene.Human molecular genetics · 2022Article
- LRMP Associates With Immune Infiltrates and Acts as a Prognostic Biomarker in Lung Adenocarcinoma.Frontiers in molecular biosciences · 2021Article
- Complex genetic control of lung tumorigenesis in resistant mice strains.Cancer science · 2017Article
- Regulatory single nucleotide polymorphisms at the beginning of intron 2 of the human KRAS gene.Journal of biosciences · 2015Article
- Decreased tumorigenesis in mice with a Kras point mutation at C118.Nature communications · 2014Article
- The error-prone DNA polymerase ι provides quantitative resistance to lung tumorigenesis and mutagenesis in mice.Oncogene · 2014Article
- Mouse pulmonary adenoma susceptibility 1 locus is an expression QTL modulating Kras-4A.PLoS genetics · 2014Article
- Genetic linkage analysis identifies Pas1 as the common locus modulating lung tumorigenesis and acute inflammatory response in mice.Genes and immunity · 2013Article
- Cancer evolution and individual susceptibility.Integrative biology : quantitative biosciences from nano to macro · 2011Review
- Most lung and colon cancer susceptibility genes are pair-wise linked in mice, humans and rats.PloS one · 2011Article
- Mapping quantitative traits and strategies to find quantitative trait genes.Methods (San Diego, Calif.) · 2011Review
- IC97 is a novel intermediate chain of I1 dynein that interacts with tubulin and regulates interdoublet sliding.Molecular biology of the cell · 2009Article
- Mouse genome-wide association mapping needs linkage analysis to avoid false-positive Loci.PLoS genetics · 2009Article
- The Kras2 oncogene and mouse lung carcinogenesis.Medical molecular morphology · 2008Review
- Cis-acting genomic elements of the Pas1 locus control Kras mutability in lung tumors.Oncogene · 2008Article
- The Idd6.2 diabetes susceptibility region controls defective expression of the Lrmp gene in nonobese diabetic (NOD) mice.Immunogenetics · 2007Article
- A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice.Nature genetics · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pulmonary adenoma susceptibility 1 (Pas1) locus affects inherited predisposition and resistance to chemically induced lung tumorigenesis in mice. The A/J and C57BL/6J mouse strains carry the susceptibility and resistance allele, respectively. We identified and genotyped 65 polymorphisms in the Pas1 locus region in 29 mouse inbred strains, and delimited the Pas1 locus to a minimal region of 468 kb containing six genes. That region defined a core Pas1 haplotype with 42 tightly linked markers, including intragenic polymorphisms in five genes (Bcat1, Lrmp, Las1, Ghiso, and Kras2) and amino-acid changes in three genes (Lrmp, Las1, Lmna-rs1). In (A/J x C57BL/6J)F1 mouse lung tumors, the Lmna-rs1 gene was completely downregulated, whereas allele-specific downregulation of the C57BL/6J-derived allele was observed at the Las1 gene, suggesting the potential role of these genes in tumor suppression. These results indicate a complex multigenic nature of the Pas1 locus, and point to a functional role for both intronic and exonic polymorphisms of the six genes of the Pas1 haplotype in lung tumor susceptibility.
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