ArticleThe Journal of physiology2004
Effects of intracellular stores and extracellular Ca(2+) on Ca(2+)-activated K(+) currents in mature mouse inner hair cells.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 96 citations in OpenAlex.
- Efferent Inhibition of Hair Cells: Past, Present and Future.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Adeno-associated virus-based rescue of Myo7a expression restores hair-cell function and improves hearing thresholds in a USH1B mouse strain.The Journal of physiology · 2025Article
- AAV-mediated rescue ofMolecular therapy. Methods & clinical development · 2022Article
- Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing.PLoS genetics · 2022Article
- BK channel activation by L-type CaJournal of neurophysiology · 2021Article
- Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness.The Journal of physiology · 2021Article
- Excess extracellular KCommunications biology · 2021Article
- Biophysical and morphological changes in inner hair cells and their efferent innervation in the ageing mouse cochlea.The Journal of physiology · 2021Article
- Pathophysiological changes in inner hair cell ribbon synapses in the ageing mammalian cochlea.The Journal of physiology · 2020Article
- Calcium-induced calcium release in proximity to hair cell BK channels revealed by PKA activation.Physiological reports · 2020Article
- Distribution and Functional Characteristics of Voltage-Gated Sodium Channels in Immature Cochlear Hair Cells.Neuroscience bulletin · 2020Article
- Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea.The Journal of physiology · 2020Article
- LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea.The Journal of physiology · 2019Article
- Differential contribution of CaThe Journal of general physiology · 2018Article
- ACh-induced hyperpolarization and decreased resistance in mammalian type II vestibular hair cells.Journal of neurophysiology · 2018Article
- Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea.Comprehensive Physiology · 2017Review
- Differential Phase Arrangement of Cellular Clocks along the Tonotopic Axis of the Mouse Cochlea Ex Vivo.Current biology : CB · 2017Article
- In vivo physiological recording from the lateral line of juvenile zebrafish.The Journal of physiology · 2016Article
- Calcium-induced calcium release supports recruitment of synaptic vesicles in auditory hair cells.Journal of neurophysiology · 2016Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ca(2+)-activated K(+) currents were studied in inner hair cells (IHCs) of mature mice. I(K,f), the large-conductance Ca(2+)-activated K(+) current (BK) characteristic of mature IHCs, had a fast activation time constant (0.4 ms at -25 mV at room temperature) and did not inactivate during 170 ms. Its amplitude, measured at -25 mV, and activation time constant were similar between IHCs in the apical and basal regions of the cochlea. I(K,f) was selectively blocked by 30 nm IbTx but was unaffected by superfusion of Ca(2+)-free solution, nifedipine or Bay K 8644, excluding the direct involvement of voltage-gated Ca(2+) channels in I(K,f) activation. Increasing the intracellular concentration of the Ca(2+) chelator BAPTA from 0.1 mm to 30 mm reduced the amplitude of I(K,f) at -25 mV and shifted its activation by 37 mV towards more depolarized potentials. A reduction in the size of I(K,f) and a depolarizing shift of its activation were also seen when either thapsigargin and caffeine or ryanodine were added intracellularly, suggesting that I(K,f) is modulated by voltage-dependent release from intracellular Ca(2+) stores. Mature IHCs had a small additional Ca(2+)-activated K(+) current (I(K(Ca))), activated by Ca(2+) flowing through L-type Ca(2+) channels. This current was still present during superfusion of either IbTx (60 nm) or apamin (300 nm) but was abolished in Cs(+)-based intracellular solution or during superfusion of 5 mm TEA, suggesting the presence of an additional BK-channel type. Current clamp experiments at body temperature show that I(K,f), but not I(K(Ca)), is essential for fast voltage responses of mature IHCs.
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