ArticleEnvironmental health perspectives2004
Molecular evidence of an interaction between prenatal environmental exposures and birth outcomes in a multiethnic population.
Article in Environmental health perspectives, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Dietary Polycyclic Aromatic Hydrocarbon (PAH) Consumption and Risk of Adverse Birth Outcomes: A Systematic Review and Meta-Analysis.Environmental health perspectives · 2024Pooled it
- The association between prenatal exposure to polycyclic aromatic hydrocarbons and birth weight: A meta-analysis.PloS one · 2020Pooled it
- Indoor exposure and adverse birth outcomes related to fetal growth, miscarriage and prematurity-a systematic review.International journal of environmental research and public health · 2014Pooled it
- Genetic variation affects congenital heart defect susceptibility in offspring exposed to maternal tobacco use.Birth defects research. Part A, Clinical and molecular teratology · 2015Trial
- Polycyclic aromatic hydrocarbons and perinatal outcomes: a scoping review.Pediatric research · 2026Review
- Prenatal air pollution exposure and placental vasculature development among participants of the UPSIDE cohort study.Environmental research · 2025Article
- Benzo[International journal of molecular sciences · 2022Review
- The effect of exposure to particulate matter during pregnancy on lower respiratory tract infection hospitalizations during first year of life.Environmental health : a global access science source · 2020Article
- Street Dust-Bound Polycyclic Aromatic Hydrocarbons in a Saudi Coastal City: Status, Profile, Sources, and Human Health Risk Assessment.International journal of environmental research and public health · 2018Article
- Cumulative Risk and Impact Modeling on Environmental Chemical and Social Stressors.Current environmental health reports · 2018Review
- Cumulative exposure to environmental pollutants during early pregnancy and reduced fetal growth: the Project Viva cohort.Environmental health : a global access science source · 2018Article
- Prenatal exposure to fine particles and polycyclic aromatic hydrocarbons and birth outcomes: a two-pollutant approach.International archives of occupational and environmental health · 2017Article
- Connecting the Dots: Linking Environmental Justice Indicators to Daily Dose Model Estimates.International journal of environmental research and public health · 2016Article
- Impact of prenatal exposure to polycyclic aromatic hydrocarbons from maternal diet on birth outcomes: a birth cohort study in Korea.Public health nutrition · 2016Article
- Ambient Air Pollution and Adverse Pregnancy Outcomes in Wuhan, China.Research report (Health Effects Institute) · 2016Article
- Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water.Critical reviews in toxicology · 2015Review
- [The effect of air pollutants on birth weight in medium-sized towns in the state of São Paulo].Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2014Article
- Epigenome: biosensor of cumulative exposure to chemical and nonchemical stressors related to environmental justice.American journal of public health · 2014Article
- Secondhand smoke exposure among nonsmoking pregnant women in New York City.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2014Article
- Separate and joint effects of tranplacental and postnatal inhalatory exposure to polycyclic aromatic hydrocarbons: prospective birth cohort study on wheezing events.Pediatric pulmonology · 2014Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Inner-city, minority populations are high-risk groups for adverse birth outcomes and also are more likely to be exposed to environmental contaminants, including environmental tobacco smoke (ETS), benzo[a]pyrene (BaP), and other polycyclic aromatic hydrocarbons (PAHs) found in urban air. In a sample of nonsmoking African-American and Dominican women, we evaluated the effects on birth outcomes of prenatal exposure to ETS, using questionnaire data and plasma cotinine as a biomarker of exposure, and environmental PAHs using BaP-DNA adducts as a molecular dosimeter. We previously reported that among African Americans, high prenatal exposure to PAHs estimated by prenatal personal air monitoring was associated with lower birth weight (p = 0.003) and smaller head circumference (p = 0.01) after adjusting for potential confounders. In the present analysis, self-reported ETS was associated with decreased head circumference (p = 0.04). BaP-DNA adducts were not correlated with ETS or dietary PAHs. There was no main effect of BaP-DNA adducts on birth outcomes. However, there was a significant interaction between the two pollutants such that the combined exposure to high ETS and high adducts had a significant multiplicative effect on birth weight (p = 0.04) and head circumference (p = 0.01) after adjusting for ethnicity, sex of newborns, maternal body mass index, dietary PAHs, and gestational age. This study provides evidence that combined exposure to environmental pollutants at levels currently encountered in New York City adversely affects fetal development.
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