ArticleMolecular and cellular biology2004
Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Liquid-liquid phase separation and its regulation of the BACH2 intrinsically disordered region.Biophysics and physicobiology · 2026Article
- Interspecies Differences in Cytomegalovirus Inhibition by Cardiac Glycosides-A Unique Role of the Alpha3 Isoform of the NaViruses · 2025Article
- Review
- Age-related changes in the BACH2 and PRDM1 genes in lymphocytes from healthy donors and chronic lymphocytic leukemia patients.BMC cancer · 2019Article
- The Bach Family of Transcription Factors: A Comprehensive Review.Clinical reviews in allergy & immunology · 2016Review
- Nucleus accumbens associated 1 is recruited within the promyelocytic leukemia nuclear body through SUMO modification.Cancer science · 2015Article
- Association investigation ofBiomedical reports · 2015Article
- Comparative ultrastructure of CRM1-Nucleolar bodies (CNoBs), Intranucleolar bodies (INBs) and hybrid PML/p62 bodies uncovers new facets of nuclear body dynamic and diversity.Nucleus (Austin, Tex.) · 2015Article
- Association between BACH2 expression and clinical prognosis in diffuse large B-cell lymphoma.Cancer science · 2014Article
- BACH2: a marker of DNA damage and ageing.DNA repair · 2013Article
- Bach2 maintains T cells in a naive state by suppressing effector memory-related genes.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- The Xanthomonas type III effector XopD targets the Arabidopsis transcription factor MYB30 to suppress plant defense.The Plant cell · 2011Article
- Stress-activated cap'n'collar transcription factors in aging and human disease.Science signaling · 2010Review
- Molecular mechanisms of Nrf2-mediated antioxidant response.Molecular carcinogenesis · 2009Review
- Identification of novel Bach2 transcripts and protein isoforms through tagging analysis of retroviral integrations in B-cell lymphomas.BMC molecular biology · 2009Article
- Sumoylation of the novel protein hRIP{beta} is involved in replication protein A deposition in PML nuclear bodies.Molecular and cellular biology · 2005Article
- Establishment of papillomavirus infection is enhanced by promyelocytic leukemia protein (PML) expression.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several lines of evidence suggest that gene expression is regulated not only by the interaction between transcription factors and DNA but also by the higher-order architecture of the cell nucleus. PML bodies are one of the most prominent nuclear substructures which have been implicated in transcription regulation during apoptosis and stress responses. Bach2 is a member of the BTB-basic region leucine zipper factor family and represses transcription activity directed by the 12-O-tetradecanoylphorbol-13-acetate response element, the Maf recognition element, and the antioxidant-responsive element. Bach2 forms nuclear foci associated with PML bodies upon oxidative stress. Here, we demonstrate that transcription activity associated with PML bodies is selectively repressed by the recruitment of Bach2 around PML bodies. Fluorescence recovery after photobleaching experiments revealed that Bach2 showed rapid turnover in the nuclear foci. The Bach2 N-terminal region including the BTB domain is essential for the focus formation. Sumoylation of Bach2 is required for the recruitment of the protein around PML bodies. These observations represent the first example of modulation of transcription activity associated with PML bodies by a sequence-specific transcription factor upon oxidative stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.