ArticleMolecular and cellular biology2004
Generation and characterization of LANP/pp32 null mice.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Acidic nuclear phosphoprotein 32A (ANP32A): structure, function, and its role in disease pathogenesis.Molecular biology reports · 2026Review
- Behavioral sensitization induced by methamphetamine causes differential alterations in gene expression and histone acetylation of the prefrontal cortex in rats.BMC neuroscience · 2021Article
- The acidic protein rich in leucines Anp32b is an immunomodulator of inflammation in mice.Scientific reports · 2019Article
- Article
- ANP32A dysregulation contributes to abnormal megakaryopoiesis in acute megakaryoblastic leukemia.Blood cancer journal · 2017Article
- Knockdown of pp32 Increases Histone Acetylation and Ameliorates Cognitive Deficits.Frontiers in aging neuroscience · 2017Article
- ANP32B deficiency impairs proliferation and suppresses tumor progression by regulating AKT phosphorylation.Cell death & disease · 2016Article
- BALB/c-congenic ANP32B-deficient mice reveal a modifying locus that determines viability.Experimental animals · 2016Article
- The expression and distributions of ANP32A in the developing brain.BioMed research international · 2015Article
- Cracking the ANP32 whips: important functions, unequal requirement, and hints at disease implications.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Article
- Overexpression of the pp32r1 (ANP32C) oncogene or its functional mutant pp32r1Y140H confers enhanced resistance to FTY720 (Finguimod).Cancer biology & therapy · 2014Article
- Glycomimetic affinity-enrichment proteomics identifies partners for a clinically-utilized iminosugar.Chemical science · 2013Article
- LANP mediates neuritic pathology in Spinocerebellar ataxia type 1.Neurobiology of disease · 2012Article
- Acidic nuclear phosphoprotein 32kDa (ANP32)B-deficient mouse reveals a hierarchy of ANP32 importance in mammalian development.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- Cpd-1 null mice display a subtle neurological phenotype.PloS one · 2010Article
- Hepatopoietin Cn suppresses apoptosis of human hepatocellular carcinoma cells by up-regulating myeloid cell leukemia-1.World journal of gastroenterology · 2010Article
- Neuronal differentiation is regulated by leucine-rich acidic nuclear protein (LANP), a member of the inhibitor of histone acetyltransferase complex.The Journal of biological chemistry · 2009Article
- The role of LANP and ataxin 1 in E4F-mediated transcriptional repression.EMBO reports · 2007Article
- The crystal structure of the tumor suppressor protein pp32 (Anp32a): structural insights into Anp32 family of proteins.Protein science : a publication of the Protein Society · 2007Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The leucine-rich acidic nuclear protein (LANP) belongs to a family of evolutionarily conserved proteins that are characterized by an amino-terminal domain rich in leucine residues followed by a carboxy-terminal acidic tail. LANP has been implicated in the regulation of a variety of cellular processes including RNA transport, transcription, apoptosis, vesicular trafficking, and intracellular signaling. Abundantly expressed in the developing cerebellum, this protein has also been hypothesized to play a role in cerebellar morphogenesis. LANP has been implicated in disease biology as well, both as a mediator of toxicity in spinocerebellar ataxia type 1 and as a tumor suppressor in cancers of the breast and prostate. To better understand the function of this multifaceted protein, we have generated mice lacking LANP. Surprisingly, these mice are viable and fertile. In addition we could not discern any derangements in any of the major organ systems, including the nervous system, which we have studied in detail. Overall our results point to a functional redundancy of LANP's function, most likely provided by its closely related family members.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.