ArticleMolecular and cellular biology2004
Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 98 citations in OpenAlex.
- A Novel Epigenetic Mechanism of Intestinal NHE3 Gene Regulation by Histone Acetylation.International journal of molecular sciences · 2026Article
- An Epigenetic Role of Mitochondria in Cancer.Cells · 2022Review
- Chromatin Dynamics in Intestinal Epithelial Homeostasis: A Paradigm of Cell Fate Determination versus Cell Plasticity.Stem cell reviews and reports · 2020Review
- Large intestine embryogenesis: Molecular pathways and related disorders (Review).International journal of molecular medicine · 2020Review
- Influence of the microbiota on epigenetics in colorectal cancer.National science review · 2019Article
- Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases.Nature communications · 2018Article
- Discovering sparse transcription factor codes for cell states and state transitions during development.eLife · 2017Article
- Ketogenesis contributes to intestinal cell differentiation.Cell death and differentiation · 2017Article
- Epigenetics in Intestinal Epithelial Cell Renewal.Journal of cellular physiology · 2016Review
- In Utero Exposure to Valproic Acid Induces Neocortical Dysgenesis via Dysregulation of Neural Progenitor Cell Proliferation/Differentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Clinacanthus nutans Protects Cortical Neurons Against Hypoxia-Induced Toxicity by Downregulating HDAC1/6.Neuromolecular medicine · 2016Article
- Delphinidin induces apoptosis via cleaved HDAC3-mediated p53 acetylation and oligomerization in prostate cancer cells.Oncotarget · 2016Article
- Identification of Histone Deacetylase 2 as a Functional Gene for Skeletal Muscle Development in Chickens.Asian-Australasian journal of animal sciences · 2016Article
- Histone deacetylase inhibition impairs normal intestinal cell proliferation and promotes specific gene expression.Journal of cellular biochemistry · 2015Article
- Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation.PLoS genetics · 2015Article
- MicroRNA-222 regulates MMP-13 via targeting HDAC-4 during osteoarthritis pathogenesis.BBA clinical · 2015Article
- Age- and pregnancy-associated DNA methylation changes in mammary epithelial cells.Stem cell reports · 2015Article
- Zinc in gut-brain interaction in autism and neurological disorders.Neural plasticity · 2015Review
- SUMO Proteins are not Involved in TGF-β1-induced, Smad3/4-mediated Germline α Transcription, but PIASy Suppresses it in CH12F3-2A B Cells.Immune network · 2014Article
- Epigenomic regulation of host-microbiota interactions.Trends in immunology · 2014Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The biochemical mechanisms underlying epigenetic control of gene expression are increasingly well known. In contrast, the contributions of individual modifications toward activation of lineage-specific genes during vertebrate development are poorly understood. Class II histone deacetylases (HDACs), which show restricted tissue distribution, regulate muscle-specific gene expression, in part through interactions with myogenic transcription factors. We have combined gene expression profiling with manipulation of fetal mouse intestinal tissue to define roles for other regulatory factors. We found that in the developing mouse intestine class I HDACs are confined to the prospective epithelium and that their levels decline coincidently with activation of differentiation genes, suggesting a functional relationship between these events. Overexpression of wild-type but not of mutant HDACs 1 and 2 in fetal intestine explants reverses expression of certain maturation markers. HDAC inhibitors, including the selective class I antagonist valproic acid, activate the same genes prematurely and accelerate cytodifferentiation. Chromatin immunoprecipitation of freshly isolated organs reveals early HDAC2 occupancy at differentiation gene promoters and corresponding histone hypoacetylation that reverses as HDAC levels fall. Thus, modulation of endogenous class I HDAC levels represents a previously unappreciated mechanism to enable onset of tissue-restricted gene expression in a developing mammalian organ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.