ArticleJournal of bacteriology2004
PhoP can activate its target genes in a PhoQ-independent manner.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- Dynamic heterogeneity in an E. coli stress response regulon mediates gene activation and antimicrobial peptide tolerance.Cell reports · 2026Article
- A novel insight into ComE-mediated activation of gene expression inMicrobiology spectrum · 2025Article
- NProceedings of the National Academy of Sciences of the United States of America · 2025Article
- An E. coli display method for characterization of peptide-sensor kinase interactions.Nature chemical biology · 2023Article
- Coordination of Phosphate and Magnesium Metabolism in Bacteria.Advances in experimental medicine and biology · 2022Article
- Methylation of PhoP by CheR RegulatesmBio · 2021Article
- How the PhoP/PhoQ System Controls Virulence and MgMicrobiology and molecular biology reviews : MMBR · 2021Review
- DNA-Binding and Transcription Activation by Unphosphorylated Response Regulator AgrR FromFrontiers in microbiology · 2020Article
- Article
- Regulatory Effect of SlyA onJournal of bacteriology · 2019Article
- Metabolic intermediate acetyl phosphate modulates bacterial virulence via acetylation.Emerging microbes & infections · 2019Article
- HilD and PhoP independently regulate the expression of grhD1, a novel gene required for Salmonella Typhimurium invasion of host cells.Scientific reports · 2018Article
- Mg2+ regulates transcription of mgtA in Salmonella Typhimurium via translation of proline codons during synthesis of the MgtL peptide.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Feedback Control of Two-Component Regulatory Systems.Annual review of microbiology · 2016Review
- Article
- Unique N-terminal arm of Mycobacterium tuberculosis PhoP protein plays an unusual role in its regulatory function.The Journal of biological chemistry · 2013Article
- Intramolecular arrangement of sensor and regulator overcomes relaxed specificity in hybrid two-component systems.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A novel two-component signaling system facilitates uropathogenic Escherichia coli's ability to exploit abundant host metabolites.PLoS pathogens · 2013Article
- SrfJ, a Salmonella type III secretion system effector regulated by PhoP, RcsB, and IolR.Journal of bacteriology · 2012Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The PhoP/PhoQ two-component system controls the extracellular magnesium depletion response in Salmonella enterica. Previous studies have shown that PhoP is unable to up-regulate its target genes in the absence of PhoQ function. In this work, we demonstrate that PhoP overexpression can substitute for PhoQ- and phosphorylation-dependent activation. Either a high concentration of PhoP or activation via phosphorylation stimulates PhoP self-association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.