ArticleGenome research2004
BAC resources for the rat genome project.
Article in Genome research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Improved protocols for BAC insert DNA isolation, BAC end sequencing and FISH for construction of BAC based physical map of genes on the chromosomes.Molecular biology reports · 2020Article
- pBACode: a random-barcode-based high-throughput approach for BAC paired-end sequencing and physical clone mapping.Nucleic acids research · 2017Article
- A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits.Frontiers in neuroscience · 2015Article
- Identifying DistalRSC advances · 2013Article
- The genome of Chelonid herpesvirus 5 harbors atypical genes.PloS one · 2012Article
- Construction of an American mink bacterial artificial chromosome (BAC) library and sequencing candidate genes important for the fur industry.BMC genomics · 2011Article
- The 19 genomes of Drosophila: a BAC library resource for genus-wide and genome-scale comparative evolutionary research.Genetics · 2011Article
- End-sequencing and characterization of silkworm (Bombyx mori) bacterial artificial chromosome libraries.BMC genomics · 2007Article
- BAC clones generated from sheared DNA.Genomics · 2007Article
- Construction of a nurse shark (Ginglymostoma cirratum) bacterial artificial chromosome (BAC) library and a preliminary genome survey.BMC genomics · 2006Article
- Construction and characterization of a genomic BAC library for the Mus m. musculus mouse subspecies (PWD/Ph inbred strain).BMC genomics · 2005Article
- Minimal cross-recombination between wild-type and loxP511 sites in vivo facilitates truncating both ends of large DNA inserts in pBACe3.6 and related vectors.Nucleic acids research · 2005Article
- A BAC-based physical map of the Drosophila buzzatii genome.Genome research · 2005Article
- A highly redundant BAC library of Atlantic salmon (Salmo salar): an important tool for salmon projects.BMC genomics · 2005Article
- Human, mouse, and rat genome large-scale rearrangements: stability versus speciation.Genome research · 2004Article
- Article
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Authors and funding
10 authors.
Funding
Abstract
Two 11-fold redundant bacterial artificial chromosome (BAC) libraries (RPCI-32 and CHORI-230) have been constructed to support the rat genome project. The first library was constructed using a male Brown Norway (BN/SsNHsd) rat as a DNA source long before plans for rat genome sequencing had been launched. The second library was prepared from a highly inbred female (BN/SsNHsd/MCW) rat in support of the rat genome sequencing project. The use of an inbred rat strain is essential to avoid problems with genome assembly resulting from the difficulty of distinguishing haplotype variation from variation among duplicons. We have demonstrated the suitability of the library by using a detailed quality assessment of large insert sizes, narrow size distribution, consistent redundancy for many markers, and long-range continuity of BAC contig maps. The widespread use of the two libraries as an integral part of the rat genome project has led to the database annotations for many clones, providing rat researchers with a rich resource of BAC clones that can be screened in silico for genes of interest.
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