ArticleGenome research2004
High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
Article in Genome research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Three decades of rat genomics: approaching the finish(ed) line.Physiological genomics · 2024Review
- Cost-Effective Mapping of Genetic Interactions in Mammalian Cells.Frontiers in genetics · 2021Article
- Pooled analysis of radiation hybrids identifies loci for growth and drug action in mammalian cells.Genome research · 2020Article
- Application of three-photon excitation FCS to the study of protein oligomerization.The journal of physical chemistry. B · 2014Article
- Pthlh, a promising cancer modifier gene in rat tongue carcinogenesis.Oncology reports · 2014Article
- Rat Strain Ontology: structured controlled vocabulary designed to facilitate access to strain data at RGD.Journal of biomedical semantics · 2013Article
- Generation and identification of rat fetal cerebral radial glia-like cells in vitro.In vitro cellular & developmental biology. Animal · 2011Article
- A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes.Genome research · 2010Article
- Every genome sequence needs a good map.Genome research · 2009Article
- Genetic determinants of hypertension: an update.Current hypertension reports · 2008Review
- A 4,103 marker integrated physical and comparative map of the horse genome.Cytogenetic and genome research · 2008Article
- MapToGenome: a comparative genomic tool that aligns transcript maps to sequenced genomes.Evolutionary bioinformatics online · 2007Article
- The genome of Apis mellifera: dialog between linkage mapping and sequence assembly.Genome biology · 2007Article
- A set of highly informative rat simple sequence length polymorphism (SSLP) markers and genetically defined rat strains.BMC genetics · 2006Article
- Efficient single nucleotide polymorphism discovery in laboratory rat strains using wild rat-derived SNP candidates.BMC genomics · 2005Article
- Tools and strategies for physiological genomics: the Rat Genome Database.Physiological genomics · 2005Article
- The Rat Genome Database (RGD): developments towards a phenome database.Nucleic acids research · 2005Article
- Article
- Integrative genomics: in silico coupling of rat physiology and complex traits with mouse and human data.Genome research · 2004Article
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 2 countries.
Funding
Abstract
The laboratory rat is a major model organism for systems biology. To complement the cornucopia of physiological and pharmacological data generated in the rat, a large genomic toolset has been developed, culminating in the release of the rat draft genome sequence. The rat draft sequence used a variety of assembly packages, as well as data from the Radiation Hybrid (RH) map of the rat as part of their validation. As part of the Rat Genome Project, we have been building a high-density RH map to facilitate data integration from multiple maps and now to help validate the genome assembly. By incorporating vectors from our lab and several other labs, we have doubled the number of simple sequence length polymorphisms (SSLPs), genes, expressed sequence tags (ESTs), and sequence-tagged sites (STSs) compared to any other genome-wide rat map, a total of 24,437 elements. During the process, we also identified a novel approach for integrating the RH placement results from multiple maps. This new integrated RH map contains approximately 10 RH-mapped elements per Mb on the genome assembly, enabling the RH maps to serve as a scaffold for a variety of data visualization tools.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.