ArticleGenome research2004
Comparative analysis of the alpha-like globin clusters in mouse, rat, and human chromosomes indicates a mechanism underlying breaks in conserved synteny.
Article in Genome research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Exploration of predictive and prognostic alternative splicing signatures in lung adenocarcinoma using machine learning methods.Journal of translational medicine · 2020Article
- A Small Key for a Heavy Door: Genetic Therapies for the Treatment of Hemoglobinopathies.Frontiers in genome editing · 2020Review
- Article
- The clustering of CpG islands may constitute an important determinant of the 3D organization of interphase chromosomes.Epigenetics · 2014Article
- TMEM8 - a non-globin gene entrapped in the globin web.Nucleic acids research · 2009Article
- BRG1 directly regulates nucleosome structure and chromatin looping of the alpha globin locus to activate transcription.Nucleic acids research · 2009Article
- Spatial configuration of the chicken alpha-globin gene domain: immature and active chromatin hubs.Nucleic acids research · 2008Article
- The human ABC transporter pseudogene family: Evidence for transcription and gene-pseudogene interference.BMC genomics · 2008Article
- Article
- The molecular basis of high-altitude adaptation in deer mice.PLoS genetics · 2007Article
- The silence RNA keeps: cis mechanisms of RNA mediated epigenetic silencing in mammals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Review
- Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Molecular basis of evolutionary events that shaped the hardness locus in diploid and polyploid wheat species (Triticum and Aegilops).The Plant cell · 2005Article
- Genes surrounding the cluster of tissue-specific alpha-globin genes in chicken genome are expressed in both erythroid and lymphoid cells.Doklady. Biochemistry and biophysicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
We have sequenced and fully annotated a 65,871-bp region of mouse Chromosome 17 including the Hba-ps4 alpha-globin pseudogene. Comparative sequence analysis with the functional alpha-globin loci at human Chromosome 16p13.3 and mouse Chromosome 11 shows that this segment of mouse Chromosome 17 contains a group of three alpha-like pseudogenes (Hba-psm-Hba-ps4-Hba-q3), similar to the duplicated sets found at the functional mouse cluster on Chromosome 11. In addition, exons 7 to 12 of the mLuc7L gene are present just downstream from the pseudogene cluster, indicating that this clone contains the region in which human 16p13.3 switches in synteny between mouse Chromosomes 11 and 17. Comparison of the sequences around the alpha-like clusters on the two mouse chromosomes reveals the presence of conserved tandem repeats. We propose that these repetitive elements have played a role in the fragmentation of the mouse alpha cluster during evolution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.