ArticleGenome research2004
Insertions and deletions are male biased too: a whole-genome analysis in rodents.
Article in Genome research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Sex Influences Genetic Susceptibility to Depression-Like Behaviors in Chronic Unpredictable Mild Stress-Exposed Wistar Rats.Molecular neurobiology · 2025Article
- Impact of Advanced Paternal Age on Fertility and Risks of Genetic Disorders in Offspring.Genes · 2023Review
- Mutational bias in spermatogonia impacts the anatomy of regulatory sites in the human genome.Genome research · 2021Article
- Variable Autosomal and X Divergence Near and Far from Genes Affects Estimates of Male Mutation Bias in Great Apes.Genome biology and evolution · 2016Article
- Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring.Reproductive biology and endocrinology : RB&E · 2015Review
- Coding sequence density estimation via topological pressure.Journal of mathematical biology · 2015Article
- Strong heterogeneity in mutation rate causes misleading hallmarks of natural selection on indel mutations in the human genome.Molecular biology and evolution · 2014Article
- "Breaking news" from spermatids.Basic and clinical andrology · 2013Article
- Unrecognized sequence homologies may confound genome-wide association studies.Nucleic acids research · 2012Article
- No evidence for a second evolutionary stratum during the early evolution of mammalian sex chromosomes.PloS one · 2012Article
- Recombination drives vertebrate genome contraction.PLoS genetics · 2012Article
- Genome analyses substantiate male mutation bias in many species.BioEssays : news and reviews in molecular, cellular and developmental biology · 2011Review
- Extraordinary sequence divergence at Tsga8, an X-linked gene involved in mouse spermiogenesis.Molecular biology and evolution · 2011Article
- A genome-wide view of mutation rate co-variation using multivariate analyses.Genome biology · 2011Article
- Environmental exposure of the mouse germ line: DNA adducts in spermatozoa and formation of de novo mutations during spermatogenesis.PloS one · 2010Article
- Doubts about complex speciation between humans and chimpanzees.Trends in ecology & evolution · 2009Article
- Human-macaque comparisons illuminate variation in neutral substitution rates.Genome biology · 2008Article
- A macaque's-eye view of human insertions and deletions: differences in mechanisms.PLoS computational biology · 2007Article
- Article
- Characteristics, causes and evolutionary consequences of male-biased mutation.Proceedings. Biological sciences · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is presently accepted that, in mammals, due to the greater number of cell divisions in the male germline than in the female germline, nucleotide substitutions occur more frequently in males. The data on mutation bias in insertions and deletions (indels) are contradictory, with some studies indicating no sex bias and others indicating either female or male bias. The sequenced rat and mouse genomes provide a unique opportunity to investigate a potential sex bias for different types of mutations. Indeed, mutation rates can be accurately estimated from a large number of orthologous loci in organisms similar in generation time and in the number of germline cell divisions. Here we compare the mutation rates between chromosome X and autosomes for likely neutral sites in eutherian ancestral interspersed repetitive elements present at orthologous locations in the rat and mouse genomes. We find that small indels are male biased: The male-to-female mutation rate ratio (alpha) for indels in rodents is approximately 2. Similarly, our whole-genome analysis in rodents indicates an approximately twofold excess of nucleotide substitutions originating in males over that in females. This is the same as the male-to-female ratio of the number of germline cell divisions in rat and mouse. Thus, this is consistent with nucleotide substitutions and small indels occurring primarily during DNA replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.