ArticleAmerican journal of respiratory cell and molecular biology2004
Differential regulation of membrane CD14 expression and endotoxin-tolerance in alveolar macrophages.
Article in American journal of respiratory cell and molecular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Lipopolysaccharide uptake is augmented in lipopolysaccharide-tolerant mouse macrophage-like cells via increased CD14 expression.FEBS open bio · 2026Article
- Aroclor 1254 inhibits anti-inflammatory macrophage polarization through an AhR-dependent mechanism.Journal of the Endocrine Society · 2026Article
- CD14 signaling mediates lung immunopathology and mice mortality induced by Achromobacter xylosoxidans.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Article
- Differential susceptibility to lipopolysaccharide affects the activation of toll-like-receptor 4 signaling in THP-1 cells and PMA-differentiated THP-1 cells.Innate immunity · 2022Article
- Bacteriophages immunomodulate the response of monocytes.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- A Novel, Five-Marker Alternative to CD16-CD14 Gating to Identify the Three Human Monocyte Subsets.Frontiers in immunology · 2019Article
- A responsive human triple-culture model of the air-blood barrier: incorporation of different macrophage phenotypes.Journal of tissue engineering and regenerative medicine · 2017Article
- Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver.World journal of gastroenterology · 2014Article
- Use of blood urea nitrogen, creatinine, interleukin-6, granulocyte-macrophage colony stimulating factor in combination to predict the severity and outcome of abdominal sepsis in rats.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Syndecan-4 regulates early neutrophil migration and pulmonary inflammation in response to lipopolysaccharide.American journal of respiratory cell and molecular biology · 2012Article
- Proteomic analysis of bronchoalveolar lavage fluid proteins from mice infected with Francisella tularensis ssp. novicida.Journal of proteome research · 2012Article
- Burkholderia pseudomallei triggers altered inflammatory profiles in a whole-blood model of type 2 diabetes-melioidosis comorbidity.Infection and immunity · 2012Article
- Optimization of a whole blood intracellular cytokine assay for measuring innate cell responses to mycobacteria.Journal of immunological methods · 2012Article
- Single nucleotide polymorphisms in the promoter of the gene encoding the lipopolysaccharide receptor CD14 are associated with bacterial diarrhea in US and Canadian travelers to Mexico.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2011Article
- TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine.Gastroenterology · 2011Article
- Polychromatic flow cytometric high-throughput assay to analyze the innate immune response to Toll-like receptor stimulation.Journal of immunological methods · 2008Article
- Increased expression and internalization of the endotoxin coreceptor CD14 in enterocytes occur as an early event in the development of experimental necrotizing enterocolitis.Journal of pediatric surgery · 2008Article
- Impaired alveolar macrophage response to Haemophilus antigens in chronic obstructive lung disease.American journal of respiratory and critical care medicine · 2006Article
- Innate immunity in the lungs.Proceedings of the American Thoracic Society · 2005Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
Abstract
CD14 is important in the clearance of bacterial pathogens from lungs. However, the mechanisms that regulate the expression of membrane CD14 (mCD14) on alveolar macrophages (AM) have not been studied in detail. This study examines the regulation of mCD14 on AM exposed to Escherichia coli in vivo and in vitro, and explores the consequences of changes in mCD14 expression. The expression of mCD14 was decreased on AM exposed to E. coli in vivo and AM incubated with lipopolysaccharide (LPS) or E. coli in vitro. Polymyxin B abolished LPS effects, but only partially blocked the effects of E. coli. Blockade of extracellular signal-regulated kinase pathways attenuated LPS and E. coli-induced decrease in mCD14 expression. Inhibition of proteases abrogated the LPS-induced decrease in mCD14 expression on AM and the release of sCD14 into the supernatants, but did not affect the response to E. coli. The production of tumor necrosis factor-alpha in response to a second challenge with Staphylococcus aureus or zymosan was decreased in AM after incubation with E. coli but not LPS. These studies show that distinct mechanisms regulate the expression of mCD14 and the induction of endotoxin tolerance in AM, and suggest that AM function is impaired at sites of bacterial infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.