ArticleArthritis research & therapy2004
Serum levels of autoantibodies against monomeric C-reactive protein are correlated with disease activity in systemic lupus erythematosus.
Article in Arthritis research & therapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 96 citations in OpenAlex.
- [Why C-reactive protein is (usually) not high in SLE].Zeitschrift fur Rheumatologie · 2026Review
- Expression characteristics of C-reactive protein in autoimmune diseases and their complications.Frontiers in immunology · 2026Article
- Review
- Monomeric CRP and negative acute phase proteins, but not pentameric CRP, as biomarkers of major depression and MDMD.Acta neuropsychiatrica · 2025Article
- Type I interferon limits interleukin-6 signalling in SLE through shedding interleukin-6 receptors.Rheumatology (Oxford, England) · 2025Article
- Simulation of the trimeric globular head of C1q reveals temperature-sensitive network: implications for inflammation.Journal of molecular modeling · 2025Article
- The Role of Anti-mCRP Autoantibodies in Lupus Nephritis.Kidney diseases (Basel, Switzerland) · 2023Review
- Associations of C-reactive protein isoforms with systemic lupus erythematosus phenotypes and disease activity.Arthritis research & therapy · 2022Article
- The Complex Role of C-Reactive Protein in Systemic Lupus Erythematosus.Journal of clinical medicine · 2021Review
- Functionality of C-Reactive Protein for Atheroprotection.Frontiers in immunology · 2019Review
- The relationship between anti-C-reactive protein and disease activity in patients with systemic lupus erythematosus.The Korean journal of internal medicine · 2018Article
- Naturally occurring antibodies against serum amyloid A reduce IL-6 release from peripheral blood mononuclear cells.PloS one · 2018Article
- Cell death in the pathogenesis of systemic lupus erythematosus and lupus nephritis.Clinical immunology (Orlando, Fla.) · 2017Review
- Tubulointerstitial nephritis and uveitis.Current opinion in ophthalmology · 2017Review
- C-reactive protein +1444CT (rs1130864) genetic polymorphism is associated with the susceptibility to systemic lupus erythematosus and C-reactive protein levels.Clinical rheumatology · 2017Article
- Clearance Deficiency and Cell Death Pathways: A Model for the Pathogenesis of SLE.Frontiers in immunology · 2016Review
- Prognostic value of anti-CRP antibodies in lupus nephritis in long-term follow-up.Arthritis research & therapy · 2015Article
- Targeting C-Reactive Protein in Inflammatory Disease by Preventing Conformational Changes.Mediators of inflammation · 2015Review
- Tubulointerstitial nephritis with uveitis in Chinese adults.Clinical journal of the American Society of Nephrology : CJASN · 2014Article
- Anti-C reactive protein antibodies in Indian patients with systemic lupus erythematosus.Indian journal of nephrology · 2013Article
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4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was performed to investigate the relation between IgG autoantibodies against human C-reactive protein (anti-CRP) and disease activity measures in serial serum samples from 10 patients with systemic lupus erythematosus (SLE), of whom four had active kidney involvement during the study period. The presence of anti-CRP was analysed by enzyme-linked immunosorbent assay. The cut-off for positive anti-CRP test was set at the 95th centile of 100 healthy blood donor sera. Specificity of the anti-CRP antibody binding was evaluated by preincubating patient sera with either native or monomeric CRP. Disease activity was determined by the SLE disease activity index (SLEDAI), serum levels of CRP, anti-DNA antibodies, complement components and blood cell counts. Of 50 serum samples, 20 (40%) contained antibodies reactive with monomeric CRP, and 7 of 10 patients were positive on at least one occasion during the study. All patients with active lupus nephritis were positive for anti-CRP at flare. Frequent correlations between anti-CRP levels and disease activity measures were observed in anti-CRP-positive individuals. Accumulated anti-CRP data from all patients were positively correlated with SLEDAI scores and anti-DNA antibody levels, whereas significant inverse relationships were noted for complement factors C1q, C3 and C4, and for lymphocyte counts. This study confirms the high prevalence of anti-CRP autoantibodies in SLE and that the antibody levels are correlated with clinical and laboratory disease activity measures. This indicates that anti-CRP antibodies might have biological functions of pathogenetic interest in SLE. Further prospective clinical studies and experimental studies on effects mediated by anti-CRP antibodies are warranted.
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