ArticleBMC genetics2004
Increasing incidence of Type 1 diabetes--role for genes?
Article in BMC genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus.The Cochrane database of systematic reviews · 2014Pooled it
- Effects of Extracellular Vesicles Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells on Cell Immunity in Nonobese Mice.Stem cells international · 2024Article
- Sex-dependent effects of bisphenol A on type 1 diabetes development in non-obese diabetic (NOD) mice.Archives of toxicology · 2019Article
- A stochastic epigenetic Mendelian oligogenic disease model for type 1 diabetes.Journal of autoimmunity · 2019Article
- Decreased levels of keratin 8 sensitize mice to streptozotocin-induced diabetes.Acta physiologica (Oxford, England) · 2018Article
- Genistein protects female nonobese diabetic mice from developing type 1 diabetes when fed a soy- and alfalfa-free diet.Toxicologic pathology · 2015Article
- Article
- Temporal trends of HLA, CTLA-4 and PTPN22 genotype frequencies among type 1 diabetes in Continental Italy.PloS one · 2013Article
- Enterovirus-induced gene expression profile is critical for human pancreatic islet destruction.Diabetologia · 2012Article
- Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk.Diabetologia · 2012Article
- Noninvasive measurement of plasma glucose from exhaled breath in healthy and type 1 diabetic subjects.American journal of physiology. Endocrinology and metabolism · 2011Article
- A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland.BMC genetics · 2007Article
- Autism, asthma, inflammation, and the hygiene hypothesis.Medical hypotheses · 2007Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe incidence of Type 1 diabetes (T1DM) is increasing fast in many populations. The reasons for this are not known, although an increase in the penetrance of the diabetes-associated alleles, through changes in the environment, might be the most plausible mechanism. After the introduction of insulin treatment in 1930s, an increase in the pool of genetically susceptible individuals has been suggested to contribute to the increase in the incidence of Type 1 diabetes.
resultsTo explore this hypothesis, the authors formulate a simple population genetic model for the incidence change driven by non-Mendelian transmission of a single susceptibility factor, either allele(s) or haplotype(s). A Poisson mixture model is used to model the observed number of cases. Model parameters were estimated by maximizing the log-likelihood function. Based on the Finnish incidence data 1965-1996 the point estimate of the transmission probability was 0.998. Given our current knowledge of the penetrance of the most diabetic gene variants in the HLA region and their transmission probabilities, this value is exceedingly unrealistic.
conclusionsAs a consequence, non-Mendelian transmission of diabetic allele(s)/haplotype(s) if present, could explain only a small part of the increase in incidence in Finland. Hence, the importance of other, probably environmental factors modifying the disease incidence is emphasized.
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