ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2004
Association between diarrhea and quality of life in HIV-infected patients receiving highly active antiretroviral therapy.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Molecular detection of Enteropathogens from diarrheic stool of HIV positive patients in Gondar, Ethiopia.BMC infectious diseases · 2018Article
- Assessing HIV and AIDS treatment safety and health-related quality of life among cohort of Malaysian patients: a discussion on methodological approach.Health expectations : an international journal of public participation in health care and health policy · 2015Article
- Functional and psychosocial impact of oral disorders and quality of life of people living with HIV/AIDS.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Article
- Noninfectious Diarrhea in HIV Seropositive Individuals: a Review of Prevalence Rates, Etiology, and Management in the Era of Combination Antiretroviral Therapy.Infectious diseases and therapy · 2014Review
- Cost effectiveness of darunavir/ritonavir combination antiretroviral therapy for treatment-naive adults with HIV-1 infection in Canada.PharmacoEconomics · 2014Article
- Review
- Health-related quality of life assessment after antiretroviral therapy: a review of the literature.Drugs · 2013Review
- Protective effects of alanyl-glutamine supplementation against nelfinavir-induced epithelial impairment in IEC-6 cells and in mouse intestinal mucosa.Cancer biology & therapy · 2012Article
- Sources of emotional distress associated with diarrhea among late middle-age and older HIV-infected adults.Journal of pain and symptom management · 2010Article
- Evaluation of HIV protease and nucleoside reverse transcriptase inhibitors on proliferation, necrosis, apoptosis in intestinal epithelial cells and electrolyte and water transport and epithelial barrier function in mice.BMC gastroenterology · 2010Article
- A new drug delivery system targeting ileal epithelial cells induced electrogenic sodium absorption: possible promotion of intestinal adaptation.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2007Article
- Diarrhea in patients with AIDS.Current treatment options in gastroenterology · 2006Article
- The two-year impact of first generation protease inhibitor based antiretroviral therapy (PI-ART) on health-related quality of life.Health and quality of life outcomes · 2005Article
Corrections and comments
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Authors and funding
17 authors at 9 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diarrhea is a common symptom that many HIV patients experience either as a consequence of HIV infection or of highly active antiretroviral therapy (HAART). A multicenter, prospective observational study was conducted in 11 AIDS clinics in Italy to determine the effect of diarrhea on health-related quality of life among patients receiving HAART. The study enrolled 100 consecutive HIV positive patients who had diarrhea while on HAART. For each enrolled patient a control patient with matching disease stage who did not have diarrhea was identified using existing data from another prospective observational study conducted in 34 AIDS clinics (including the 11 in current study). Quality of life was measured by MOS-HIV Health Survey (MOS-HIV). Paired t-test and multiple regression analysis were used to compare the quality of life among patients with and without diarrhea. Mean patient age was 40 +/- 7 years; 69% were male. Mean CD4 cell count was 342 +/- 239 cells/mm3; 59% had AIDS. Of the cases, 49 patients had severe diarrhea (> 5 bowel movements or > 3 watery per day) and 46 patients had moderate diarrhea (3-5 bowel movements). Compared to matched control patients, cases experiencing diarrhea while on HAART had significantly lower MOS-HIV scores in all domains. The significant adverse effect of diarrhea on quality of life should be considered when choosing the appropriate antiretroviral drugs regimen.
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