ArticleProceedings. Biological sciences2004
Molecular design of the alpha-keratin composite: insights from a matrix-free model, hagfish slime threads.
Article in Proceedings. Biological sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 103 citations in OpenAlex.
- Influence of experimental methods on the mechanical properties of silk fibers: A systematic literature review and future road map.Biophysics reviews · 2023Review
- Article
- Extensible and self-recoverable proteinaceous materials derived from scallop byssal thread.Nature communications · 2022Article
- The next generation of protein super-fibres: robust recombinant production and recovery of hagfish intermediate filament proteins with fibre spinning and mechanical-structural characterizations.Microbial biotechnology · 2021Article
- Structure of Keratin.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Progress in Modern Marine Biomaterials Research.Marine drugs · 2020Review
- Keratin Associations with Synthetic, Biosynthetic and Natural Polymers: An Extensive Review.Polymers · 2019Review
- Effect of ionic strength and seawater cations on hagfish slime formation.Scientific reports · 2018Article
- Human nail plate modifications induced by onychomycosis: implications for topical therapy.Pharmaceutical research · 2015Article
- Structural proteins from whelk egg capsule with long range elasticity associated with a solid-state phase transition.Biomacromolecules · 2014Article
- Regulation of hard α-keratin mechanics via control of intermediate filament hydration: matrix squeeze revisited.Proceedings. Biological sciences · 2013Article
- Pseudoelastic behaviour of a natural material is achieved via reversible changes in protein backbone conformation.Journal of the Royal Society, Interface · 2012Article
- Nanoscale strain-hardening of keratin fibres.PloS one · 2012Article
- Intermediate filaments regulate tissue size and stiffness in the murine lens.Investigative ophthalmology & visual science · 2011Article
- Evidence that αC region is origin of low modulus, high extensibility, and strain stiffening in fibrin fibers.Biophysical journal · 2010Article
- Calcification provides mechanical reinforcement to whale baleen alpha-keratin.Proceedings. Biological sciences · 2010Article
- Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia.Journal of anatomy · 2009Review
- Tensile properties of single desmin intermediate filaments.Biophysical journal · 2008Article
- A comparison of the mechanical and structural properties of fibrin fibers with other protein fibers.Cell biochemistry and biophysics · 2007Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed mechanical tests on a matrix-free keratin model-hagfish slime threads-to test the hypothesis that intermediate filaments (IFs) in hydrated hard alpha-keratins are maintained in a partly dehydrated state. This hypothesis predicts that dry IFs should possess mechanical properties similar to the properties of hydrated hard alpha-keratins, and should swell more than hard alpha-keratins in water. Mechanical and swelling measurements of hagfish threads were consistent with both of these predictions, suggesting that an elastomeric keratin matrix resists IF swelling and keeps IF stiffness and yield stress high. The elastomeric nature of the matrix is indirectly supported by the inability of matrix-free IFs (i.e. slime threads) to recover from post-yield deformation. We propose a general conceptual model of the structural mechanics of IF-based materials that predicts the effects of hydration and cross-linking on stiffness, yield stress and extensibility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.