SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2004
Haplotype analysis of VDR gene polymorphisms: a meta-analysis.
Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between phosphodiesterase 4D gene and ischaemic stroke.Journal of neurology, neurosurgery, and psychiatry · 2006Pooled it
- A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia.European journal of epidemiology · 2006Pooled it
- Vitamin D Receptor Polymorphisms and Their Association with Nrf2-Dependent Gene Expression in Oxidative Stress Resilience in Cognitively Healthy Aging.Antioxidants (Basel, Switzerland) · 2026Article
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- Vitamin D Receptor (Genes · 2022Article
- Vitamin D receptor gene polymorphisms in chronic kidney disease Egyptian children: effect on biochemical markers of bone mineral disorders.Pediatric endocrinology, diabetes, and metabolism · 2022Article
- Vitamin D receptor gene polymorphisms and risk of breast cancer in Iranian women.Annals of medicine and surgery (2012) · 2022Article
- Vitamin D Status, Bone Mineral Density, andNutrients · 2021Article
- Skeletal Abnormalities and VDR1 Gene Polymorphisms in Mucopolysaccharidosis Patients.Pharmacogenomics and personalized medicine · 2021Article
- Immunogenetic Prediction of VDR Gene SNPs: Lack of Association with Susceptibility to Type 1 Diabetes in Jordanian Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Vitamin D Status in Russian Children and Adolescents: Contribution of Genetic and Exogenous Factors.Frontiers in pediatrics · 2020Article
- Association of Vitamin D Receptor BsmI Gene Polymorphism with BMD Z-Score in Iranian Children and Adolescents (9 - 18 Years Old).International journal of endocrinology and metabolism · 2019Article
- Association of Vitamin D Receptor Gene Variation With Osteoporosis Risk in Belarusian and Lithuanian Postmenopausal Women.Frontiers in endocrinology · 2018Article
- Association between the vitamin D receptor gene polymorphism and osteoporosis.Biomedical reports · 2016Article
- Article
- Association between vitamin D receptor polymorphisms and osteoporosis in patients with COPD.International journal of chronic obstructive pulmonary disease · 2015Article
- Association of vitamin D receptor FokI and ApaI polymorphisms with lung cancer risk in Tunisian population.Molecular biology reports · 2014Article
- Association between vitamin D receptor gene polymorphisms (Fok1 and Bsm1) and osteoporosis: a systematic review.Journal of diabetes and metabolic disorders · 2014Article
- Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes.Evolution, medicine, and public health · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlthough many studies have addressed the relationship between multiple individual polymorphisms in the vitamin D receptor (VDR) gene and bone health, few have analyzed this data in terms of haplotypes. We performed a meta-analysis of studies with data on the BsmI, ApaI, and TaqI polymorphisms in order to (a) estimate haplotype frequencies, (b) determine linkage disequilibrium (LD), and (c) estimate the magnitude of the association between haplotypes and osteoporosis/bone mineral density (BMD).
methodsHaplotypes were inferred using the expectation-maximization algorithm (EM); log-linear models were used to determine association with osteoporosis; and regression analysis with variance components was used to determine association with BMD.
resultsOur results indicate that the most common haplotype for the VDR gene, regardless of ethnicity, is baT, followed by BAt and bAT in Caucasians, and bAT and BaT in Asians. This indicates strong LD between the BsmI and TaqI polymorphisms. We demonstrate a gain in power when considering the haplotypes rather than the individual polymorphisms separately, i.e., although BsmI, ApaI, and TaqI were not significantly associated with osteoporosis on their own, the haplotypes Bat and BAt were significantly associated, with an OR of approximately 4.
conclusionWe have applied haplotype analysis to the VDR polymorphisms and bone measures. We also highlight a number of methodologic issues, including linkage disequilibrium, the robustness of the EM algorithm in this context, and the potential for exploring effect modification.
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Registered trials
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