ArticleGenes and immunity2004
A systematic approach to the assessment of known TNF-alpha polymorphisms in Graves' disease.
Article in Genes and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Gene polymorphisms of pro-inflammatory cytokines may affect the risk of Graves' disease: a meta-analysis.Journal of endocrinological investigation · 2021Pooled it
- Association ofBioscience reports · 2018Pooled it
- A single tumour necrosis factor haplotype influences the response to adalimumab in rheumatoid arthritis.Annals of the rheumatic diseases · 2008Trial
- Article
- Polymorphisms in the TNFA and IL6 genes represent risk factors for autoimmune thyroid disease.PloS one · 2014Article
- Association between age at diagnosis of Graves' disease and variants in genes involved in immune response.PloS one · 2013Article
- Article
- Immunogenetic mechanisms leading to thyroid autoimmunity: recent advances in identifying susceptibility genes and regions.Current genomics · 2011Article
- Article
- Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms.Endocrine reviews · 2008Review
- Recent insights into the pathogenesis and management of thyroid-associated ophthalmopathy.Current opinion in endocrinology, diabetes, and obesity · 2008Review
- Cytokines, Graves' disease, and thyroid-associated ophthalmopathy.Thyroid : official journal of the American Thyroid Association · 2008Review
- The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency.Respiratory research · 2008Article
- The HLA Region and Autoimmune Disease: Associations and Mechanisms of Action.Current genomics · 2007Article
- Tumor necrosis factor-alpha gene polymorphism correlates with cardiovascular disease in patients with end-stage renal disease.Molecular diagnosis & therapy · 2007Article
- TNFalpha mediates the skeletal effects of thyroid-stimulating hormone.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes.Diabetologia · 2005Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single-nucleotide polymorphisms (SNPs) within the tumour necrosis factor alpha (TNF-alpha) gene on chromosome 6p21.3 have been associated with many autoimmune diseases; however, results have been conflicting and accurate allele frequencies have never been established in a UK Caucasian population. The aim of this study was to assess the frequency of 22 known TNF-alpha SNPs in a UK Caucasian control population and investigate association of all polymorphisms with >5% minor allele frequency in a large case-control data set of patients with Graves' disease (GD). Eight of the 22 SNPs had minor allele frequencies >5% and were investigated further. The other 14 SNPs were present in the UK population at frequencies ranging from 0 to 4.7%. A significant increase of the A allele of the -238 SNP was seen in GD patients when compared with control subjects (9.6 vs 6.8%, respectively; P=0.003) and mirrored in the genotype distribution (P=0.009). Furthermore, association of the -238 SNP appears not to be due to linkage disequilibrium of the known HLA-DRB1(*)03 associations with GD. This study has established accurate allele frequencies of TNF-alpha SNPs in a UK population and provides preliminary evidence for association of the TNF-alpha gene with GD.
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