ArticleGene therapy2004
Endothelial progenitor cells' "homing" specificity to brain tumors.
Article in Gene therapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 90 citations in OpenAlex.
- Understanding the role of endothelial cells in brain tumor formation and metastasis: a proposition to be explored for better therapy.Journal of the National Cancer Center · 2023Review
- Hematopoietic stem cells as a tool for the treatment of glioblastoma multiforme.Molecular medicine reports · 2016Article
- Cancer stem cells and microglia in the processes of glioblastoma multiforme invasive growth.Oncology letters · 2016Article
- A putative nitroreductase from the DosR regulon of Mycobacterium tuberculosis induces pro-inflammatory cytokine expression via TLR2 signaling pathway.Scientific reports · 2016Article
- Inflammatory properties of inhibitor of DNA binding 1 secreted by synovial fibroblasts in rheumatoid arthritis.Arthritis research & therapy · 2016Article
- Use of genetically engineered stem cells for glioma therapy.Oncology letters · 2016Article
- The expression of P2X₇ receptors in EPCs and their potential role in the targeting of EPCs to brain gliomas.Cancer biology & therapy · 2015Article
- Article
- Inhibitor of DNA binding 1 as a secreted angiogenic transcription factor in rheumatoid arthritis.Arthritis research & therapy · 2014Article
- Monitoring adenoviral based gene delivery in rat glioma by molecular imaging.World journal of clinical oncology · 2013Article
- Evidence that CXCL16 is a potent mediator of angiogenesis and is involved in endothelial progenitor cell chemotaxis : studies in mice with K/BxN serum-induced arthritis.Arthritis and rheumatism · 2013Article
- Endothelial progenitor cells homing to the orthotopic implanted liver tumor of nude mice.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2012Article
- Tumor microenvironment in the brain.Cancers · 2012Article
- Mesenchymal stem cell-mediated cancer therapy: A dual-targeted strategy of personalized medicine.World journal of stem cells · 2011Article
- Review
- A review of VEGF/VEGFR-targeted therapeutics for recurrent glioblastoma.Journal of the National Comprehensive Cancer Network : JNCCN · 2011Review
- Concise review: Nanoparticles and cellular carriers-allies in cancer imaging and cellular gene therapy?Stem cells (Dayton, Ohio) · 2010Review
- The role and therapeutic potential of endothelial progenitor cells in tumor neovascularization.TheScientificWorldJournal · 2010Review
- Toward brain tumor gene therapy using multipotent mesenchymal stromal cell vectors.Molecular therapy : the journal of the American Society of Gene Therapy · 2010Review
- Adenoviral-mediated endothelial precursor cell delivery of soluble CD115 suppresses human prostate cancer xenograft growth in mice.Stem cells (Dayton, Ohio) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current treatment of malignant glioma brain tumors is unsatisfactory. Gene therapy has much promise, but target-specific vectors are needed. Endothelial progenitor cells (EPCs) have in vivo homing specificity to angiogenic sites and are thus potential vehicles for site-specific gene therapy. However, reports of EPCs "homing" to intracranial solid tumors are lacking. We investigated EPCs' "homing" specificity using a murine intracranial glioma model. EPCs, derived from human cord blood, were labeled with a fluorogenic agent CFSE and intravenously injected into SCID mice bearing orthotopic gliomas. At 7-14 days after EPC injection, mouse brains and other vital organs were examined for distribution of transplanted EPCs. As controls, CFSE-labeled human umbilical vein endothelial cells (HUVECs) and EPCs were intravenously injected into matched glioma SCID mice (HUVEC control groups) and nontumor SCID mice (nontumor-bearing control groups), respectively. Fluorescence image analysis revealed that systemically transplanted EPCs 'homed' to brain tumors with significantly higher specificity as compared to other organs within the experimental group (P<0.001) and to anatomically matched brain sections from the control groups (P<0.001). Our study demonstrates EPCs' in vivo tropism for intracranial gliomas, with potential for cell delivery of brain tumor spatial-specific gene therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.