Evidence map›Paper›PMID 15056710›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004

Extracellular signal-regulated kinases regulate dendritic growth in rat sympathetic neurons.

In-Jung Kim, Karen M Drahushuk, Woo-Yang Kim, Eugene A Gonsiorek, Pamela Lein, Douglas A Andres, Dennis Higgins

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. GRM2 Regulates Functional Integration of Adult-Born DGCs by Paradoxically Modulating MEK/ERK1/2 Pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
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  7. What Do We Really Know About 5-HTFrontiers in cellular neuroscience · 2016
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Dendrite complexity of sympathetic neurons is controlled during postnatal development by BMP signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013
    Article
  13. Article
  14. Article
  15. The novel GTPase Rit differentially regulates axonal and dendritic growth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007
    Article
  16. Article
  17. Serotonin 5-HT1A receptors regulate NMDA receptor channels through a microtubule-dependent mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005
    Article
  18. Regulation of NMDA receptors by neuregulin signaling in prefrontal cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

In-Jung KimDepartment of Pharmacology and Toxicology, State University of New York, Buffalo, New York 14214, USA.
Karen M Drahushuk
Woo-Yang Kim
Eugene A Gonsiorek
Pamela Lein
Douglas A Andres
Dennis Higgins
University at Buffalo, State University of New York · USBuffalo State University · USInstitute of Developmental Physiology · RUUniversity of Kentucky · US

Funding

Retrograde Dystrophic Influence of IFN-gamma on NeuronsR01NS046649 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEIN, PAMELA J · 2003 to 2006
$1.0M
NINDS NIH HHS NS46649NINDS NIH HHS R01 NS046649
6 · The paper itself

Abstract

NGF activates several signaling cascades in sympathetic neurons. We examined how activation of one of these cascades, the ERK/MAP (extracellular signal-regulated kinase/mitogen-activated protein) kinase pathway, affects dendritic growth in these cells. Dendritic growth was induced by exposure to NGF and BMP-7 (bone morphogenetic protein-7). Exposure to NGF increased phosphorylation of ERK1/2. Unexpectedly, two MEK (MAP kinase kinase) inhibitors (PD 98059 and U 0126) enhanced dendritic growth, and a ligand, basic FGF, that activates the ERK pathway inhibited the growth of these processes. The enhancement of dendritic growth by PD 98059 was associated with an increase in the number of axo-dendritic synapses, and it appeared to represent a specific morphogenic effect because neither axonal growth nor cell survival was affected. In addition, increased dendritic growth was not observed after exposure to inhibitors of other signaling pathways, including the phosphatidylinositol-3-kinase inhibitor LY 294002. Dendritic growth was also increased in cells transfected with dominant-negative mutants of MEK1 and ERK2 but not with dominant-negative mutants of MEK5 and ERK5, suggesting that ERK1/2 is the primary mediator of this effect. Exposure to BMP-7 induces nuclear translocation of Smad1 (Sma- and Mad-related protein 1), and PD 98059 treatment potentiated nuclear accumulation of Smad-1 induced by BMP-7 in sympathetic neurons, suggesting a direct enhancement of BMP signaling in cells treated with an MEK inhibitor. These observations indicate that one of the signaling cascades activated by NGF can act in an antagonistic manner in sympathetic neurons and reduce the dendritic growth induced by other NGF-sensitive pathways.

Indexed as

Active Transport, Cell NucleusAnimalsBone Morphogenetic Protein 7Bone Morphogenetic ProteinsCell CountCell DifferentiationCell NucleusCells, CulturedDendritesDNA-Binding ProteinsEnzyme InhibitorsFibroblast Growth FactorsFlavonoidsGenes, DominantHumansMitogen-Activated Protein Kinase 12-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-oneBMP7 protein, humanBmp7 protein, ratBone Morphogenetic Protein 7Bone Morphogenetic ProteinsDNA-Binding ProteinsEnzyme InhibitorsFibroblast Growth FactorsFlavonoidsMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Mitogen-Activated Protein Kinase KinasesMitogen-Activated Protein KinasesSmad1 ProteinSMAD1 protein, humanSmad1 protein, ratSmad ProteinsTrans-ActivatorsTransforming Growth Factor beta

Identifiers

PMID15056710
PMCPMC6730016
OpenAlexW1983578575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.