ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Pavlovian fear conditioning regulates Thr286 autophosphorylation of Ca2+/calmodulin-dependent protein kinase II at lateral amygdala synapses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 132 citations in OpenAlex.
- Experience-dependent critical period for synaptic plasticity in the rat olfactory amygdala.Frontiers in synaptic neuroscience · 2026Review
- The Molecular Substrates of Second-Order Conditioned Fear in the Basolateral Amygdala Complex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Second-order threat conditioning in the amygdala-posterior piriform cortex network.Communications biology · 2025Article
- The Basolateral Amygdala: The Core of a Network for Threat Conditioning, Extinction, and Second-Order Threat Conditioning.Biology · 2023Review
- The ERK phosphorylation levels in the amygdala predict anxiety symptoms in humans and MEK/ERK inhibition dissociates innate and learned defensive behaviors in rats.Molecular psychiatry · 2021Article
- The Calcium/Calmodulin-Dependent Kinases II and IV as Therapeutic Targets in Neurodegenerative and Neuropsychiatric Disorders.International journal of molecular sciences · 2021Review
- Fear Memory Retrieval Is Associated With a Reduction in AMPA Receptor Density at Thalamic to Amygdala Intercalated Cell Synapses.Frontiers in synaptic neuroscience · 2021Article
- CaMKII antagonism in the ventral tegmental area impairs acquisition of conditioned approach learning in rats.Neurobiology of learning and memory · 2020Article
- NPYThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Neurochemical and molecular mechanisms underlying the retrieval-extinction effect.Psychopharmacology · 2019Review
- Kinase and Phosphatase Engagement Is Dissociated Between Memory Formation and Extinction.Frontiers in molecular neuroscience · 2019Article
- Mechanisms of fear learning and extinction: synaptic plasticity-fear memory connection.Psychopharmacology · 2019Review
- Commonalities and Differences in the Substrates Underlying Consolidation of First- and Second-Order Conditioned Fear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Traumatic Stress Produces Distinct Activations of GABAergic and Glutamatergic Neurons in Amygdala.Frontiers in neuroscience · 2018Article
- Cue-induced reinstatement of alcohol-seeking behavior is associated with increased CaMKII T286 phosphorylation in the reward pathway of mice.Pharmacology, biochemistry, and behavior · 2017Article
- Age-dependent changes in autophosphorylation of alpha calcium/calmodulin dependent kinase II in hippocampus and amygdala after contextual fear conditioning.Brain research bulletin · 2017Article
- Neurobiology of fear and specific phobias.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Review
- Is Arc mRNA Unique: A Search for mRNAs That Localize to the Distal Dendrites of Dentate Gyrus Granule Cells Following Neural Activity.Frontiers in molecular neuroscience · 2017Article
- From Structure to Behavior in Basolateral Amygdala-Hippocampus Circuits.Frontiers in neural circuits · 2017Review
- Phosphoproteomic Analysis Reveals a Novel Mechanism of CaMKIIα Regulation Inversely Induced by Cocaine Memory Extinction versus Reconsolidation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays a critical role in synaptic plasticity and memory formation in a variety of learning systems and species. The present experiments examined the role of CaMKII in the circuitry underlying pavlovian fear conditioning. First, we reveal by immunocytochemical and tract-tracing methods that alphaCaMKII is postsynaptic to auditory thalamic inputs and colocalized with the NR2B subunit of the NMDA receptor. Furthermore, we show that fear conditioning results in an increase of the autophosphorylated (active) form of alphaCaMKII in lateral amygdala (LA) spines. Next, we demonstrate that intra-amygdala infusion of a CaMK inhibitor, 1-[NO-bis-1,5-isoquinolinesulfonyl]-N-methyl-l-tyrosyl-4-phenylpiperazine, KN-62, dose-dependently impairs the acquisition, but not the expression, of auditory and contextual fear conditioning. Finally, in electrophysiological experiments, we demonstrate that an NMDA receptor-dependent form of long-term potentiation at thalamic input synapses to the LA is impaired by bath application of KN-62 in vitro. Together, the results of these experiments provide the first comprehensive view of the role of CaMKII in the amygdala during fear conditioning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.