ArticleLipids2004
Dietary diacylglycerol prevents high-fat diet-induced lipid accumulation in rat liver and abdominal adipose tissue.
Article in Lipids, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 106 citations in OpenAlex.
- Integrative multi-omics analysis reveals molecular signatures of central obesity in children.Pediatric research · 2025Article
- Hepatic Lipidomics Unravels the Lipid-Lowering and Anti-Obesity Efficacy of Diacylglycerol Oil: Mechanistic Insights From High-Fat Diet-Induced Obese Mice.Food science & nutrition · 2025Article
- Comprehensive lipidomic analysis of the lipids extracted from freshwater fish bones and crustacean shells.Food science & nutrition · 2022Article
- High fat-low protein diet induces metabolic alterations and cognitive dysfunction in female rats.Metabolic brain disease · 2019Article
- Metabolomics signatures associated with an oral glucose challenge in pregnant women.Diabetes & metabolism · 2019Article
- Role of SREBPs in Liver Diseases: A Mini-review.Journal of clinical and translational hepatology · 2018Review
- Article
- Preparation of Diacylglycerol from Lard by Enzymatic Glycerolysis and Its Compositional Characteristics.Korean journal for food science of animal resources · 2017Article
- The Effects of a High Fat Diet Containing Diacylglycerol on Bone in C57BL/6J Mice.Yonsei medical journal · 2015Article
- Plastids of marine phytoplankton produce bioactive pigments and lipids.Marine drugs · 2013Review
- Substitution of TAG oil with diacylglycerol oil in food items improves the predicted 10 years cardiovascular risk score in healthy, overweight subjects.Journal of nutritional science · 2012Article
- Electrospray ionization tandem mass spectrometry of sodiated adducts of cholesteryl esters.Lipids · 2011Article
- Scientific Opinion on the substantiation of a health claim related to diacylglycerol (DAG) oil and reduction of body weight pursuant to Article 13(5) of Regulation (EC) No 1924/2006.EFSA journal. European Food Safety Authority · 2011Article
- Analysis of cholesteryl esters and diacylglycerols using lithiated adducts and electrospray ionization-tandem mass spectrometry.Analytical biochemistry · 2011Article
- Effects of a single and short-term ingestion of diacylglycerol on fat oxidation in rats.Lipids · 2008Article
- Effect of diacylglycerol on the development of impaired glucose tolerance in sucrose-fed rats.Lipids · 2006Article
- Comparison of the lymphatic transport of radiolabeled 1,3-dioleoylglycerol and trioleoylglycerol in rats.Lipids · 2004Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inhibitory effects of 1,3-diacylglycerol (DAG) on diet-induced lipid accumulation in liver and abdominal adipose tissue of rats were investigated in the present study. Male Sprague-Dawley rats were given free access to diets containing 7 wt% TAG (low TAG), 20 wt% TAG (high TAG), or 20 wt% DAG (high DAG), respectively, for 8 wk. The body weight of rats in the 20% high-TAG group increased significantly, and the weights of their abdominal adipose tissue and liver also showed a significant increase compared with rats in the low-TAG group. However, the high-DAG diet resulted in both a significant reduction in body weight gain (with a decrease of 70.5%) and an increase in the ratio of abdominal fat to body weight (by 127%) compared with the high-TAG diet. As well, the liver TAG and serum TAG levels of the high-DAG group were significantly lower than those of the high-TAG group. These effects were associated with up-regulation of acyl-CoA carnitine acyltransferase (ACAT) and down-regulation of acyl-CoA DAG acyltransferase (DGAT) in the liver. However, no significant difference was observed in the activities of alanine aminotransferase and aspartate aminotransferase among the groups (P > 0.05). The present results indicate that dietary DAG reduced fat accumulation in viscera and body, and these effects may be involved with up-regulation of ACAT and down-regulation of DGAT in the liver.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.