ArticlePediatric nephrology (Berlin, Germany)2004
The safety and use of short-acting nifedipine in hospitalized hypertensive children.
Article in Pediatric nephrology (Berlin, Germany), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 42 citations in OpenAlex.
- Long-acting nifedipine in the management of essential hypertension: a review for cardiologists.American journal of cardiovascular disease · 2024Review
- Virtual Clinical Trials Guided Design of an Age-Appropriate Formulation and Dosing Strategy of Nifedipine for Paediatric Use.Pharmaceutics · 2023Article
- Management and outcomes of acute post-streptococcal glomerulonephritis in children.World journal of nephrology · 2022Review
- Management of Hypertensive Crises in Children: A Review of the Recent Literature.Frontiers in pediatrics · 2022Review
- Epidemiology and Management of Children with Hypertensive Crisis: A Single-Center Experience.Journal of pediatric intensive care · 2020Article
- A Practical Guide to the Management of Severe Hypertension in Children.Paediatric drugs · 2020Article
- Hypertension in children in emergency department.Journal of renal injury prevention · 2016Article
- Therapy of acute hypertension in hospitalized children and adolescents.Current hypertension reports · 2014Review
- Old habits die hard: a nationwide utilization study of short-acting nifedipine in Taiwan.PloS one · 2014Article
- Evaluation and management of pediatric hypertensive crises: hypertensive urgency and hypertensive emergencies.Open access emergency medicine : OAEM · 2012Review
- Hypertensive emergencies in children.Indian journal of pediatrics · 2011Article
- Short- and long-term physiologic and pharmacologic control of blood pressure in pediatric patients.Integrated blood pressure control · 2011Article
- Isradipine for treatment of acute hypertension in hospitalized children and adolescents.Journal of clinical hypertension (Greenwich, Conn.) · 2010Article
- Management of acute kidney injury in children: a guide for pediatricians.Paediatric drugs · 2008Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent reports suggest that calcium channel blockers are harmful in the treatment of acute hypertension in adults. However, short-acting nifedipine is an effective and useful medication in pediatric hypertension and is currently utilized for hypertensive emergencies. This study will address these safety concerns in hypertensive children. Medical records (from five Canadian pediatric hospitals) of all pediatric hypertensive hospitalized children who were treated with short-acting nifedipine from January 1995 to December 1998 were retrospectively reviewed for patient demographics, dosing regimen, use of concomitant medications, co-morbid conditions, and presence/absence of minor and serious adverse events. Final data were extracted from 182 patients. Each patient had an average of 2.6 episodes of hypertension in hospital that required treatment, totaling 477 episodes. Within the 477 episodes, 1,162 doses of short-acting nifedipine were administered. The mean dose was 0.22 mg/kg (range 0.043-0.67 mg/kg, median 0.19 mg/kg) with 55.6% (260/468 episodes) receiving the drug via the sublingual route. Hypertension resolved in 85.5% (408/477) of the episodes. There were only 29 of 574 (5.1%) minor adverse events that were definitely or probably related to short-acting nifedipine administration. Two patients experienced a serious adverse event that involved of a reduction in blood pressure of more than 40%, but neither had any symptomatology from the serious adverse event and recovered spontaneously within 2 h. Short-acting nifedipine in hypertensive, hospitalized children appears to be a safe and efficacious medication with minimal side effects.
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