Evidence map›Paper›PMID 15054437›Full record

Trial reportEuropean journal of clinical nutrition2004

Vitamin A status and hemoglobin concentrations are improved in Indonesian children with vitamin A and deworming interventions.

S A Tanumihardjo, D Permaesih, Muhilal

Registry-linked trialAbstract readClinical TrialRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00936091 (Effects of Vitamin A Supplementation on Intestinal Parasitic Reinfections, Growth, Iron Status and Educational Achievement Among Orang Asli Schoolchildren in Pos Betau, Pahang, Malaysia), which is not on this map. Cited by 24 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 7 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00936091 nacompletednot on this mapstarted 2007, after this paper: background citation

Effects of Vitamin A Supplementation on Intestinal Parasitic Reinfections, Growth, Iron Status and Educational Achievement Among Orang Asli Schoolchildren in Pos Betau, Pahang, Malaysia

TypeinterventionalSponsorSana'a UniversityRan2007 to 2008Enrolled250ConditionsIntestinal Parasitic Infections, Malnutrition, AnemiaArmsvitamin A supplements, Placebo
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 7 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Anthelmintic drugs for treating ascariasis.The Cochrane database of systematic reviews · 2020
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  20. Vitamin A: biomarkers of nutrition for development.The American journal of clinical nutrition · 2011
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

S A TanumihardjoDepartment of Nutritional Sciences, UW-Madison, Madison, WI 53706, USA. sherry@nutrisci.wisc.edu
D Permaesih
Muhilal
University of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAnemia is a major public health problem caused by multiple factors. Vitamin A (VA) depletion can affect hemoglobin concentration (Hb). This study investigated the improvement in Hb and VA status in preschool Indonesian children following supplementation with 210 micromol VA and deworming with 400 mg albendazole. SUBJECTS AND

designIndonesian children (n = 131) infected with Ascaris lumbricoides and/or Trichuris trichiura were enrolled. The children were grouped by length of time since receiving 210 micromol VA through the local health system. Group 1 (VA administered > or = 4 month before baseline) included 51 children with Ascaris and 29 children with Trichuris. Group 2 had received VA < or = 1 month of baseline from the local health post and included 51 children. INTERVENTION AND

methodsImmediately following baseline Hb and VA status assessment (modified relative dose response (MRDR) test), Group 1 children were given 210 micromol VA and 400 mg albendazole. Group 2 were randomized to be dewormed either 1 week before, at the same time or 1 week after baseline MRDR and Hb measures. Follow-up assessment was 3-4 weeks after baseline.

resultsVA status in Group 1 significantly improved in children with either Ascaris (P < 0.0001) or Trichuris (P = 0.028). Although the prevalence of anemia declined, the improvement in Hb was not significant (P = 0.08). In Group 2, improvement in VA status from the VA delivered through the public health system was maintained for more than 1 month. Hb improved (P = 0.0037) and this improvement appeared to be associated with the length of time between deworming and follow-up assessments.

conclusionPublic health supplementation programs to improve VA status may also increase Hb concentrations and decrease anemia prevalence, especially when linked to deworming. SPONSORSHIP: These studies were supported by the Thrasher Research Fund, SmithKline Beecham and Hatch-Wisconsin Agricultural Experiment Station number WIS04533.

Indexed as

AlbendazoleAnemiaAnimalsAnthelminticsAscariasisAscaris lumbricoidesChild, PreschoolDietary SupplementsFemaleHemoglobinsHumansIndonesiaIntestinal Diseases, ParasiticMaleNutritional StatusTrichuriasisAlbendazoleAnthelminticsHemoglobinsVitamin A

Identifiers

PMID15054437
OpenAlexW1991170616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.