Trial reportEuropean journal of clinical nutrition2004
High-dose intravenous vitamin C is not associated with an increase of pro-oxidative biomarkers.
Trial report in European journal of clinical nutrition, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- The impact of vitamin C supplementation in pregnancy and in vitro upon fetal membrane strength and remodeling.Reproductive sciences (Thousand Oaks, Calif.) · 2010Trial
- Postoperative Delirium and Vitamin C: Rethinking Unfavorable Outcomes Through the Lens of Underdosing.Journal of clinical medicine research · 2025Article
- Oxidative stress and retinopathy: evidence from epidemiological studies.Journal of translational medicine · 2025Article
- Review
- Effect of Physiological Concentrations of Vitamin C on the Inhibitation of Hydroxyl Radical Induced Light Emission from FeMolecules (Basel, Switzerland) · 2021Article
- High-Dose Intravenous Ascorbic Acid: Ready for Prime Time in Traumatic Brain Injury?Neurocritical care · 2020Article
- The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome.Redox biology · 2019Review
- Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid.Nutrients · 2018Review
- Intravenous Vitamin C for Cancer Therapy - Identifying the Current Gaps in Our Knowledge.Frontiers in physiology · 2018Review
- Effect of High-Dose Vitamin C Infusion in a Glucose-6-Phosphate Dehydrogenase-Deficient Patient.Case reports in medicine · 2017Article
- Vitamin C in Health and Disease: Its Role in the Metabolism of Cells and Redox State in the Brain.Frontiers in physiology · 2015Review
- Contrasting effects of ascorbate and iron on the pulmonary vascular response to hypoxia in humans.Physiological reports · 2014Article
- There's life in the old dog yet: vitamin C as a therapeutic option in endothelial dysfunction.Critical care (London, England) · 2014Article
- Evaluation of vitamin C for adjuvant sepsis therapy.Antioxidants & redox signaling · 2013Review
- Natural antioxidants and hypertension: promise and challenges.Cardiovascular therapeutics · 2010Review
- Inflammatory response in microvascular endothelium in sepsis: role of oxidants.Journal of clinical biochemistry and nutrition · 2008Article
- Mechanism of action of vitamin C in sepsis: ascorbate modulates redox signaling in endothelium.BioFactors (Oxford, England)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHigh-dose vitamin C therapy might mediate beneficial clinical effects by counteracting reactive oxygen species. However, concerns are raised whether this approach might provoke diametrical (ie pro-oxidative) effects. The objective was to determine ascorbyl free radical (AFR) concentrations and potential variables of pro-oxidative damage.
designCrossover study; six healthy males received daily infusions of 750 or 7500 mg vitamin C for six consecutive days. Fasting concentrations of vitamin C and AFR were determined daily. On day 1, concentrations of vitamin C and AFR were measured at 0.25, 0.5, 1, 2, 4 and 8 h post infusion. Plasma concentrations of thiobarbituric acid-reactive substances (TBARS), tocopherol and urine concentrations of 8-oxoguanosine were determined on days 1 and 6.
resultsKinetic studies on day 1 showed that concentrations of vitamin C and AFR displayed parallel dose- and time-dependent kinetics and elimination was highly efficient. Vitamin C and AFR fasting concentrations on days 2-6 were slightly above the baseline, suggesting new, stable steady states. TBARS decreased in both groups, whereas tocopherol and 8-oxoguanosine concentrations remained unchanged.
conclusionKinetics of AFR largely depend on plasma vitamin C concentrations and AFR is eliminated efficiently. Our data do not support induction of pro-oxidative effects in healthy volunteers given intravenous high-dose vitamin C. SPONSORSHIP: Pascoe Pharmazeutische Präparate GmbH, Giessen, Germany.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.