ArticleBMC clinical pharmacology2004
Physiologically based pharmacokinetic modeling of arterial - antecubital vein concentration difference.
Article in BMC clinical pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Sensitivity of [(11)C]ORM-13070 to increased extracellular noradrenaline in the CNS - a PET study in human subjects.Psychopharmacology · 2015Trial
- Heterogeneity of human adipose blood flow.BMC clinical pharmacology · 2007Trial
- Manuscript DMD-D-25-00346 The impact of glycocalyx on partitioning and distribution of basic drugs.Drug metabolism and disposition: the biological fate of chemicals · 2026Article
- Review
- Cerebral venous biomarkers and veno-arterial gradients: untapped resources in Alzheimer's disease.Frontiers in neurology · 2023Article
- A permeability- and perfusion-based PBPK model for improved prediction of concentration-time profiles.Clinical and translational science · 2022Article
- Consideration of Fractional Distribution Parameter fPharmaceutical research · 2022Article
- Sampling Site Has a Critical Impact on Physiologically Based Pharmacokinetic Modeling.The Journal of pharmacology and experimental therapeutics · 2020Article
- PKQuest: PBPK modeling of highly lipid soluble and extracellular solutes.ADMET & DMPK · 2019Article
- Use Of Quantitative Modelling To Elucidate The Roles Of The Liver, Gut, Kidney, And Muscle In Ammonia Homeostasis And How Lactulose And Rifaximin Alter This Homeostasis.International journal of general medicine · 2019Review
- Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.CPT: pharmacometrics & systems pharmacology · 2016Article
- Blood-borne biomarkers and bioindicators for linking exposure to health effects in environmental health science.Journal of toxicology and environmental health. Part B, Critical reviews · 2016Review
- Are Physiologically Based Pharmacokinetic Models Reporting the Right C(max)? Central Venous Versus Peripheral Sampling Site.The AAPS journal · 2015Article
- Article
- PKQuest_Java: free, interactive physiologically based pharmacokinetic software package and tutorial.BMC research notes · 2009Article
- PBTK modeling demonstrates contribution of dermal and inhalation exposure components to end-exhaled breath concentrations of naphthalene.Environmental health perspectives · 2007Article
- Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat.BMC clinical pharmacology · 2006Article
- Human physiologically based pharmacokinetic model for propofol.BMC anesthesiology · 2005Article
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1 author.
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Abstract
backgroundModeling of pharmacokinetic parameters and pharmacodynamic actions requires knowledge of the arterial blood concentration. In most cases, experimental measurements are only available for a peripheral vein (usually antecubital) whose concentration may differ significantly from both arterial and central vein concentration.
methodsA physiologically based pharmacokinetic (PBPK) model for the tissues drained by the antecubital vein (referred to as "arm") is developed. It is assumed that the "arm" is composed of tissues with identical properties (partition coefficient, blood flow/gm) as the whole body tissues plus a new "tissue" representing skin arteriovenous shunts. The antecubital vein concentration depends on the following parameters: the fraction of "arm" blood flow contributed by muscle, skin, adipose, connective tissue and arteriovenous shunts, and the flow per gram of the arteriovenous shunt. The value of these parameters was investigated using simultaneous experimental measurements of arterial and antecubital concentrations for eight solutes: ethanol, thiopental, 99Tcm-diethylene triamine pentaacetate (DTPA), ketamine, D2O, acetone, methylene chloride and toluene. A new procedure is described that can be used to determine the arterial concentration for an arbitrary solute by deconvolution of the antecubital concentration. These procedures are implemented in PKQuest, a general PBPK program that is freely distributed http://www.pkquest.com.
resultsOne set of "standard arm" parameters provides an adequate description of the arterial/antecubital vein concentration for ethanol, DTPA, thiopental and ketamine. A significantly different set of "arm" parameters was required to describe the data for D2O, acetone, methylene chloride and toluene - probably because the "arm" is in a different physiological state.
conclusionsUsing the set of "standard arm" parameters, the antecubital vein concentration can be used to determine the whole body PBPK model parameters for an arbitrary solute without any additional adjustable parameters. Also, the antecubital vein concentration can be used to estimate the arterial concentration for an arbitrary input for solutes for which no arterial concentration data is available.
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