ArticleWorld journal of gastroenterology2004
Ginkgo biloba extract reverses CCl4-induced liver fibrosis in rats.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Study of the effect of bezafibrate with ginkgo biloba extracts in an animal model of hepatotoxicity induced by doxorubicin.Biochemistry and biophysics reports · 2023Article
- Uridine alleviates carbon tetrachloride-induced liver fibrosis by regulating the activity of liver-related cells.Journal of cellular and molecular medicine · 2022Article
- Protective Effects ofInternational journal of environmental research and public health · 2019Article
- Herbal remedies for liver fibrosis: A review on the mode of action of fifty herbs.Journal of traditional and complementary medicine · 2018Review
- Ginkgo biloba extract mitigates liver fibrosis and apoptosis by regulating p38 MAPK, NF-κB/IκBα, and Bcl-2/Bax signaling.Drug design, development and therapy · 2015Article
- Hydrodynamics-based transfection of rat interleukin-10 gene attenuates porcine serum-induced liver fibrosis in rats by inhibiting the activation of hepatic stellate cells.International journal of molecular medicine · 2014Article
- Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis.Chinese medicine · 2014Article
- Liver fibrosis and protection mechanisms action of medicinal plants targeting apoptosis of hepatocytes and hepatic stellate cells.Advances in pharmacological sciences · 2014Review
- Attenuating effect of Ginkgo biloba leaves extract on liver fibrosis induced by thioacetamide in mice.Journal of biomedicine & biotechnology · 2012Article
- Filtrate of fermented mycelia from Antrodia camphorata reduces liver fibrosis induced by carbon tetrachloride in rats.World journal of gastroenterology · 2006Article
- Therapeutic effect of interleukin-10 on CCl4-induced hepatic fibrosis in rats.World journal of gastroenterology · 2006Article
- Effect of Astragalus complanatus flavonoid on anti-liver fibrosis in rats.World journal of gastroenterology · 2005Article
- Hepatic fibrosis in biliary-obstructed rats is prevented by Ginkgo biloba treatment.World journal of gastroenterology · 2005Article
- Protective effects of 5,4'-dihydroxy-3',5'-dimethoxy-7-O-beta-D -glucopyranosyloxy-flavone on experimental hepatic injury.World journal of gastroenterology · 2005Article
- Complementary and alternative medicine in the treatment of chronic liver disease.Current gastroenterology reports · 2005Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the reversing effect of Ginkgo biloba extract (GbE) on established liver fibrosis in rats.
methodsFollowing confirmation of CCl(4)-induced liver fibrosis, GbE or saline was administrated to the rats for 4 weeks. The remaining rats received neither CCl(4) nor GbE as normal control. The four groups were compared in terms of serum enzymes, tissue damage, expression of alphaSMA and tissue inhibitor-1 of metalloproteinase (TIMP-1) and metalloproteinase-1 (MMP-1).
resultsCompared with saline-treated group, liver fibrosis rats treated with GbE had decreased serum total bilirubin (P<0.01) and aminotransferase levels (P<0.01) and increased levels of serum albumin (P<0.01). Microscopic studies revealed that the livers of rats receiving GbE showed alleviation in fibrosis (P<0.05) as well as expression of alphaSMA (P<0.01). The liver collagen and reticulum contents were lower in rats treated with GbE than saline-treated group (P<0.01). RT-PCR revealed that the level of TIMP-1 decreased while the level of MMP-1 increased in GbE group.
conclusionAdministration of GbE improved CCl(4)-induced liver fibrosis. It is possibly attributed to its effect of inhibiting the expression of TIMP-1 and promoting the apoptosis of hepatic stellate cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.