ArticleWorld journal of gastroenterology2004
Ketamine suppresses intestinal NF-kappa B activation and proinflammatory cytokine in endotoxic rats.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- Ketamine does not inhibit interleukin-6 synthesis in hepatic resections requiring a temporary porto-arterial occlusion (Pringle manoeuvre): a controlled, prospective, randomized, double-blinded study.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2011Trial
- Effect of intraocular surgery and ketamine on aqueous and serum cytokines.Molecular vision · 2007Trial
- Anesthetic management of patients with sepsis/septic shock.Frontiers in medicine · 2023Review
- Simulated altitude exercise training damages small intestinal mucosa barrier in the rats.Journal of exercise rehabilitation · 2018Article
- Ozone preconditioning and exposure to ketamine attenuates hepatic inflammation in septic rats.Archives of medical science : AMS · 2012Article
- The Role of Th17 in Neuroimmune Disorders: A Target for CAM Therapy. Part III.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Applied information retrieval and multidisciplinary research: new mechanistic hypotheses in complex regional pain syndrome.Journal of biomedical discovery and collaboration · 2007Article
- Ketamine-induced gastroprotection during endotoxemia: role of heme-oxygenase-1.Digestive diseases and sciences · 2006Article
- Effect of glutamate on inflammatory responses of intestine and brain after focal cerebral ischemia.World journal of gastroenterology · 2005Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the protective effect of ketamine on the endotoxin-induced proinflammatory cytokines and NF-kappa B activation in the intestine.
methodsAdult male Wistar rats were randomly divided into 6 groups: (a) normal saline control, (b) challenged with endotoxin (5 mg/kg) and treated by saline, (c) challenged with endotoxin (5 mg/kg) and treated by ketamine (0.5 mg/kg), (d) challenged with endotoxin (5 mg/kg) and treated by ketamine (5 mg/kg ), (e) challenged with endotoxin (5 mg/kg) and treated by ketamine (50 mg/kg), and (f) saline injected and treated by ketamine (50 mg/kg). After 1, 4 or 6 h, TNF-alpha and IL-6 mRNA were investigated in the tissues of the intestine (jejunum) by RT-PCR. TNF-alpha and IL-6 were measured by ELISA. We used electrophoretic mobility shift assay (EMSA) to investigate NF-kappa B activity in the intestine.
resultsNF-kappa B activity, the expression of TNF-alpha and IL-6 were enhanced in the intestine by endotoxin. Ketamine at a dose of 0.5 mg/kg could suppress endotoxin-induced TNF-alpha mRNA and protein elevation and inhibit NF-kappa B activation in the intestine. However the least dosage of ketamine to inhibit IL-6 was 5 mg/kg in our experiment.
conclusionKetamine can suppress endotoxin-induced production of proinflammatory cytokines such as TNF-alpha and IL-6 production in the intestine. This suppressive effect may act through inhibiting NF-kappa B.
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Registered trials
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