Trial reportWorld journal of gastroenterology2004
Pre-treatment urea breath test results predict the efficacy of Helicobacter pylori eradication therapy in patients with active duodenal ulcers.
Trial report in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Sequential versus standard triple first-line therapy for Helicobacter pylori eradication.The Cochrane database of systematic reviews · 2016Pooled it
- The sequential therapy regimen for Helicobacter pylori eradication: a pooled-data analysis.Gut · 2007Pooled it
- 13C-urea breath test values and Helicobacter pylori eradication.Digestive diseases and sciences · 2008Trial
- Interpretation of the 13C-urea breath test in the choice of second- and third-line eradication of Helicobacter pylori infection.Journal of gastroenterology · 2008Trial
- Sequential versus Standard Triple Therapy for First-LineAntibiotics (Basel, Switzerland) · 2024Review
- Diagnostic Methods of Helicobacter pylori Infection for Epidemiological Studies: Critical Importance of Indirect Test Validation.BioMed research international · 2016Review
- Role of gastritis pattern on Helicobacter pylori eradication.Internal and emergency medicine · 2012Article
- Helicobacter pylori therapy: Present and future.World journal of gastrointestinal pharmacology and therapeutics · 2012Article
- Update on non-bismuth quadruple (concomitant) therapy for eradication of Helicobacter pylori.Clinical and experimental gastroenterology · 2012Article
- Helicobacter pylori detection and antimicrobial susceptibility testing.Clinical microbiology reviews · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the association of pre-treatment (13)C-urea breath test (UBT) results with H pylori density and efficacy of eradication therapy in patients with active duodenal ulcers.
methodsOne hundred and seventeen consecutive outpatients with active duodenal ulcer and H pylori infection were recruited. H pylori density was histologically graded according to the Sydney system. Each patient received lansoprazole (30 mg b.i.d.), clarithromycin (500 mg b.i.d.) and amoxicillin (1 g b.i.d.) for 1 week. According to pre-treatment UBT values, patients were allocated into low (<16 per thousand), intermediate (16-35 per thousand), and high (>35 per thousand) UBT groups.
resultsA significant correlation was found between pre-treatment UBT results and H pylori density (P<0.001). H pylori eradication rates were 94.9%, 94.4% and 81.6% in the low, intermediate and high UBT groups, respectively (per protocol analysis, P=0.11). When patients were assigned into two groups (UBT results < or =35 per thousand and >35 per thousand), the eradication rates were 94.7% and 81.6%, respectively (P=0.04).
conclusionThe intragastric bacterial load of H pylori can be evaluated by UBT, and high pre-treatment UBT results can predict an adverse outcome of eradication therapy.
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