Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Normal values and within-subject variability of cardiac I-123 MIBG scintigraphy in healthy individuals: implications for clinical studies.
Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03084679 (Characterization of Myocardial Interstitial Fibrosis and Cardiomyocyte Hypertrophy by Cardiac MRI In Heart Failure), which is not on this map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characterization of Myocardial Interstitial Fibrosis and Cardiomyocyte Hypertrophy by Cardiac MRI In Heart Failure: Implication on Early Remodeling and on the Transition to Heart Failure
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- Proposal for standardization of 123I-metaiodobenzylguanidine (MIBG) cardiac sympathetic imaging by the EANM Cardiovascular Committee and the European Council of Nuclear Cardiology.European journal of nuclear medicine and molecular imaging · 2010Guideline
- Cardiac resynchronization therapy upregulates cardiac autonomic control.Journal of cardiovascular electrophysiology · 2008Trial
- The neuronal imaging in cardiology: 123I-Biophysical reviews · 2025Review
- [Diagnostics (Basel, Switzerland) · 2025Article
- Illuminating the Hidden: Standardizing Cardiac MIBG Imaging for Sympathetic Dysfunction.Journal of nuclear medicine technology · 2025Review
- Cardiac 123I-Metaiodobenzylguanidine (MIBG) Scintigraphy in Parkinson's Disease: A Comprehensive Review.Brain sciences · 2023Review
- Anger recall mental stress decreasesJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Cardiac sympathetic innervation in Parkinson's disease versus multiple system atrophy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Uniformity of cardiacJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Calibrated scintigraphic imaging procedures improve quantitative assessment of the cardiac sympathetic nerve activity.Scientific reports · 2020Article
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Influence of ROI definition on the heart-to-mediastinum ratio in planarJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Renal sympathetic nerve activity after catheter-based renal denervation.EJNMMI research · 2018Article
- Ventricular arrhythmias and autonomic nervous system: evolving role of radionuclide imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- The natural history of takotsubo syndrome: a two-year follow-up study with myocardial sympathetic and perfusion G-SPECT imaging.European journal of nuclear medicine and molecular imaging · 2017Article
- Cardiac sympathetic innervation associates with autonomic dysfunction in chronic fatigue syndrome - a pilot study.Fatigue : biomedicine, health & behavior · 2017Article
- Development and validation of a direct-comparison method for cardiac (123)I-metaiodobenzylguanidine washout rates derived from late 3-hour and 4-hour imaging.European journal of nuclear medicine and molecular imaging · 2016Article
- Cardiac sympathetic imaging in the diagnosis of cardiac autonomic neuropathy in pre-diabetes.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- The Utility of Segmental Analysis in Cardiac I-123 MIBG SPECT in Parkinson's Disease.Nuclear medicine and molecular imaging · 2015Article
- Individuals with impaired glucose tolerance demonstrate normal cardiac sympathetic innervation using I-123 mIBG scintigraphy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough several myocardial iodine 123 metaiodobenzylguanidine (MIBG) indices are increasingly used to detect alterations in myocardial sympathetic activity in various forms of cardiac pathology, published measurements of normal values and within-subject variability are lacking. METHODS AND
resultsTwenty-five healthy volunteers underwent planar and single photon emission computed tomography (SPECT) imaging. Heart-mediastinum ratio (H/M) and myocardial washout were calculated from planar images comparing three different methods for the assessment of myocardial activity: (1) global region over the myocardium (cavity included), (2) global region over the myocardium (cavity excluded), and (3) fixed small myocardial region. Segmental (relative) uptake and washout were assessed by SPECT. For all MIBG indices, the interindividual variation was the lowest for methods 1 and 2. In SPECT this variation was low for relative segmental uptake compared with washout. In 9 subjects a second MIBG scintigraphy was performed after 3 months. The within-subject variability of H/M and washout assessed by planar methods 1 and 2 was 5%, whereas it was approximately 9% for planar method 3. For relative segmental uptake from SPECT, this variability was 5%.
conclusionMIBG H/M (planar) and relative segmental uptake (SPECT) show a low interindividual and within-subject variability. This enables the detection of small (regional) variations in myocardial sympathetic nervous function, especially to monitor the effect of therapeutic interventions in patients with various cardiac diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.