ArticleProceedings of the National Academy of Sciences of the United States of America2004
RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 88 citations in OpenAlex.
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- FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21(Cip1/Waf1).The Biochemical journal · 2015Article
- MiR-181 family: regulators of myeloid differentiation and acute myeloid leukemia as well as potential therapeutic targets.Oncogene · 2015Article
- miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stress.Cell death & disease · 2013Article
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- NotI microarrays: novel epigenetic markers for early detection and prognosis of high grade serous ovarian cancer.International journal of molecular sciences · 2012Article
- Tumor-suppressive microRNA silenced by tumor-specific DNA hypermethylation in cancer cells.Cancer science · 2012Review
- MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein.Nucleic acids research · 2012Article
- MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia.Oncogene · 2012Article
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Authors and funding
20 authors at 2 institutions in 2 countries.
Funding
Abstract
Chromosome 3p21.3 region is frequently (>90%) deleted in lung and other major human carcinomas. We subdivided 3p21.3 into LUCA and AP20 subregions and discovered frequent homozygous deletions (10-18%) in both subregions. This finding strongly implies that they harbor multiple tumor suppressor genes involved in the origin and/or development of major epithelial cancers. In this study, we performed an initial analysis of RBSP3/HYA22, a candidate tumor suppressor genes located in the AP20 region. Two sequence splice variants of RBSP3/HYA22 (A and B) were identified, and we provide evidence for their tumor suppressor function. By sequence analysis RBSP3/HYA22 belongs to a gene family of small C-terminal domain phosphatases that may control the RNA polymerase II transcription machinery. Expression of the gene was drastically (>20-fold) decreased in 11 of 12 analyzed carcinoma cell lines and in three of eight tumor biopsies. We report missense and nonsense mutations in tumors where RBSP3/HYA22 was expressed, growth suppression with regulated transgenes in culture, suppression of tumor formation in severe combined immunodeficient mice, and dephosphorylation of ppRB by RBSP3/HYA22, presumably leading to a block of the cell cycle at the G1/S boundary.
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