ArticleProceedings of the National Academy of Sciences of the United States of America2004
Distinguishing human ethnic groups by means of sequences from Helicobacter pylori: lessons from Ladakh.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed, 151 citations in OpenAlex.
- Pathogenomics of Helicobacter pylori.Current topics in microbiology and immunology · 2023Review
- Within-community variation of interspecific divergence patterns in passerine gut microbiota.Ecology and evolution · 2022Article
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- A 500-year tale of co-evolution, adaptation, and virulence: Helicobacter pylori in the Americas.The ISME journal · 2021Article
- Molecular Phylogenetic Analysis ofInternational journal of microbiology · 2020Article
- Comparative study between Helicobacter pylori and host human genetics in the Dominican Republic.BMC evolutionary biology · 2019Article
- Ventilatory parameters at rest after months of stay at 3300 m: A comparison between acclimatized lowlanders and natives at Leh.Medical journal, Armed Forces India · 2019Article
- Tipping the Scale Toward Gastric Disease: A Host-Pathogen Genomic Mismatch?Current genetic medicine reports · 2018Article
- Cooperation of Gastric Mononuclear Phagocytes withJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- From Evolutionary Advantage to Disease Agents: Forensic Reevaluation of Host-Microbe Interactions and Pathogenicity.Microbiology spectrum · 2017Review
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- How old are bacterial pathogens?Proceedings. Biological sciences · 2016Review
- Genome-wide mosaicism within Mycobacterium abscessus: evolutionary and epidemiological implications.BMC genomics · 2016Article
- The 5300-year-old Helicobacter pylori genome of the Iceman.Science (New York, N.Y.) · 2016Article
- Article
- Human Genetic Ancestral Composition Correlates with the Origin of Mycobacterium leprae Strains in a Leprosy Endemic Population.PLoS neglected tropical diseases · 2015Article
- Molecular Epidemiology of Helicobacter pylori Infection in Nepal: Specific Ancestor Root.PloS one · 2015Article
- Friend and foe: factors influencing the movement of the bacterium Helicobacter pylori along the parasitism-mutualism continuum.Evolutionary applications · 2015Review
- Global analysis of saliva as a source of bacterial genes for insights into human population structure and migration studies.BMC evolutionary biology · 2014Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 2 institutions in 2 countries.
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Abstract
The history of mankind remains one of the most challenging fields of study. However, the emergence of anatomically modern humans has been so recent that only a few genetically informative polymorphisms have accumulated. Here, we show that DNA sequences from Helicobacter pylori, a bacterium that colonizes the stomachs of most humans and is usually transmitted within families, can distinguish between closely related human populations and are superior in this respect to classical human genetic markers. H. pylori from Buddhists and Muslims, the two major ethnic communities in Ladakh (India), differ in their population-genetic structure. Moreover, the prokaryotic diversity is consistent with the Buddhists having arisen from an introgression of Tibetan speakers into an ancient Ladakhi population. H. pylori from Muslims contain a much stronger ancestral Ladakhi component, except for several isolates with an Indo-European signature, probably reflecting genetic flux from the Near East. These signatures in H. pylori sequences are congruent with the recent history of population movements in Ladakh, whereas similar signatures in human microsatellites or mtDNA were only marginally significant. H. pylori sequence analysis has the potential to become an important tool for unraveling short-term genetic changes in human populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.