ArticleThe Journal of cell biology2004
The p75NTR-interacting protein SC1 inhibits cell cycle progression by transcriptional repression of cyclin E.
Article in The Journal of cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 68 citations in OpenAlex.
- Emerging Role of HDACs in Regeneration and Ageing in the Peripheral Nervous System: Repair Schwann Cells as Pivotal Targets.International journal of molecular sciences · 2022Review
- The Effect of Physical Activity on Neurotrophin Concentrations and Cognitive Control in Patients With a Depressive Episode.Frontiers in psychiatry · 2022Article
- Review
- Defined factors to reactivate cell cycle activity in adult mouse cardiomyocytes.Scientific reports · 2019Article
- Zebrafish prdm12b acts independently of nkx6.1 repression to promote eng1b expression in the neural tube p1 domain.Neural development · 2019Article
- PI3Ka-Akt1-mediated Prdm4 induction in adipose tissue increases energy expenditure, inhibits weight gain, and improves insulin resistance in diet-induced obese mice.Cell death & disease · 2018Article
- Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150Developmental cell · 2018Article
- Identification of Prdm genes in human corneal endothelium.Experimental eye research · 2017Article
- ESM1 mediates NGFR-induced invasion and metastasis in murine oral squamous cell carcinoma.Oncotarget · 2016Article
- Article
- An emerging role for prdm family genes in dorsoventral patterning of the vertebrate nervous system.Neural development · 2015Review
- Role of p75 neurotrophin receptor in stem cell biology: more than just a marker.Cellular and molecular life sciences : CMLS · 2014Review
- p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells.The Journal of biological chemistry · 2014Article
- The PR/SET domain zinc finger protein Prdm4 regulates gene expression in embryonic stem cells but plays a nonessential role in the developing mouse embryo.Molecular and cellular biology · 2013Article
- Differential regulation of SC1/PRDM4 and PRMT5 mediated protein arginine methylation by the nerve growth factor and the epidermal growth factor in PC12 cells.Neuroscience letters · 2013Article
- PRDM Proteins: Molecular Mechanisms in Signal Transduction and Transcriptional Regulation.Biology · 2013Article
- Transcription factor positive regulatory domain 4 (PRDM4) recruits protein arginine methyltransferase 5 (PRMT5) to mediate histone arginine methylation and control neural stem cell proliferation and differentiation.The Journal of biological chemistry · 2012Article
- Nerve growth factor induces cell cycle arrest of astrocytes.Developmental neurobiology · 2012Article
- How histone deacetylases control myelination.Molecular neurobiology · 2011Review
- Cell proliferation and interleukin-6-type cytokine signaling are implicated by gene expression responses in early optic nerve head injury in rat glaucoma.Investigative ophthalmology & visual science · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Schwann cell factor 1 (SC1), a p75 neurotrophin receptor-interacting protein, is a member of the positive regulatory/suppressor of variegation, enhancer of zeste, trithorax (PR/SET) domain-containing zinc finger protein family, and it has been shown to be regulated by serum and neurotrophins. SC1 shows a differential cytoplasmic and nuclear distribution, and its presence in the nucleus correlates strongly with the absence of bromodeoxyuridine (BrdU) in these nuclei. Here, we investigated potential transcriptional activities of SC1 and analyzed the function of its various domains. We show that SC1 acts as a transcriptional repressor when it is tethered to Gal4 DNA-binding domain. The repressive activity requires a trichostatin A-sensitive histone deacetylase (HDAC) activity, and SC1 is found in a complex with HDACs 1, 2, and 3. Transcriptional repression exerted by SC1 requires the presence of its zinc finger domains and the PR domain. Additionally, these two domains are involved in the efficient block of BrdU incorporation by SC1. The zinc finger domains are also necessary to direct SC1's nuclear localization. Lastly, SC1 represses the promoter of a promitotic gene, cyclin E, suggesting a mechanism for how growth arrest is regulated by SC1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.