ReviewCellular and molecular neurobiology2004
Molecular signals into the insular cortex and amygdala during aversive gustatory memory formation.
Review in Cellular and molecular neurobiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 64 citations in OpenAlex.
- Subchronic SSRI administration reduces insula response during affective anticipation in healthy volunteers.The international journal of neuropsychopharmacology · 2009Trial
- Intranasal Administration of Rotenone Reduces GABAergic Inhibition in the Mouse Insular Cortex Leading to Impairment of LTD and Conditioned Taste Aversion Memory.International journal of molecular sciences · 2020Article
- Taste Processing: Insights from Animal Models.Molecules (Basel, Switzerland) · 2020Review
- CB1 cannabinoid receptor-mediated plasticity of GABAergic synapses in the mouse insular cortex.Scientific reports · 2020Article
- Interoceptive Insular Cortex Mediates Both Innate Fear and Contextual Threat Conditioning to Predator Odor.Frontiers in behavioral neuroscience · 2019Article
- Multisynaptic Projections from the Amygdala to the Ventral Premotor Cortex in Macaque Monkeys: Anatomical Substrate for Feeding Behavior.Frontiers in neuroanatomy · 2018Article
- Effects of lesions in different nuclei of the amygdala on conditioned taste aversion.Experimental brain research · 2017Article
- Picture free recall performance linked to the brain's structural connectome.Brain and behavior · 2017Article
- Upregulation of orexin/hypocretin expression in aged rats: Effects on feeding latency and neurotransmission in the insular cortex.Neuroscience · 2017Article
- Estradiol enhances the acquisition of lithium chloride-induced conditioned taste aversion in castrated male rats.Die Naturwissenschaften · 2015Article
- Effect of preexposure on methylphenidate-induced taste avoidance and related BDNF/TrkB activity in the insular cortex of the rat.Psychopharmacology · 2015Article
- Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction.Neural regeneration research · 2015Article
- Enduring effects of tacrine on cocaine-reinforced behavior: Analysis by conditioned-place preference, temporal separation from drug reward, and reinstatement.Pharmacological research · 2015Article
- Microglial activation enhances associative taste memory through purinergic modulation of glutamatergic neurotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The insula modulates arousal-induced reluctance to try novel tastes through adrenergic transmission in the rat.Frontiers in behavioral neuroscience · 2015Article
- Medial prefrontal cortex dopamine controls the persistent storage of aversive memories.Frontiers in behavioral neuroscience · 2014Article
- Involvement of the insular cortex in regulating glucocorticoid effects on memory consolidation of inhibitory avoidance training.Frontiers in behavioral neuroscience · 2012Article
- The age of anxiety: role of animal models of anxiolytic action in drug discovery.British journal of pharmacology · 2011Review
- Calcium binding proteins immunoreactivity in the rat basolateral amygdala following myocardial infarction.Cellular and molecular neurobiology · 2010Article
- Associatively learned representations of taste outcomes activate taste-encoding neural ensembles in gustatory cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, we will provide evidence of the putative molecular signals and biochemical events that mediate the formation of long-lasting gustatory memory trace. When an animal drinks a novel taste (the conditioned stimulus; CS) and it is later associated with malaise (unconditioned stimulus; US), the animal will reject it in the next presentation, developing a long-lasting taste aversion, i.e., the taste cue becomes an aversive signal, and this is referred to as conditioning taste aversion. Different evidence indicates that the novel stimulus (taste) induces a rapid and strong cortical acetylcholine activity that decreases when the stimulus becomes familiar after several presentations. Cholinergic activation via muscarinic receptors initiates a series of intracellular events leading to plastic changes that could be related to short- and/or long-term memory gustatory trace. Such plastic changes facilitate the incoming US signals carried out by, in part, the glutamate release induced by the US. Altogether, these events could produce the cellular changes related to the switch from safe to aversive taste memory trace. A proposed working model to explain the biochemical sequence of signals during taste memory formation will be discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.