ArticlePflugers Archiv : European journal of physiology2004
Potassium kinetics in human muscle interstitium during repeated intense exercise in relation to fatigue.
Article in Pflugers Archiv : European journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Sodium bicarbonate intake improves high-intensity intermittent exercise performance in trained young men.Journal of the International Society of Sports Nutrition · 2015Trial
- The influence of acetaminophen on repeated sprint cycling performance.European journal of applied physiology · 2014Trial
- Dietary nitrate supplementation improves team sport-specific intense intermittent exercise performance.European journal of applied physiology · 2013Trial
- Fatiguing high-intensity intermittent exercise depresses maximal NaPflugers Archiv : European journal of physiology · 2025Article
- Temporal dynamics of the interstitial fluid proteome in human skeletal muscle following exhaustive exercise.Science advances · 2025Article
- A century of exercise physiology: effects of muscle contraction and exercise on skeletal muscle NaEuropean journal of applied physiology · 2024Review
- Exercise and fatigue: integrating the role of KEuropean journal of applied physiology · 2023Review
- Muscle Glycogen Metabolism and High-Intensity Exercise Performance: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2021Review
- Low-load resistance training to task failure with and without blood flow restriction: muscular functional and structural adaptations.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Effects of natural polyphenol-rich pomegranate juice supplementation on plasma ion and lipid profiles following resistance exercise: a placebo-controlled trial.Nutrition & metabolism · 2020Article
- Potassium chloride released from contracting skeletal muscle may stimulate development of its hypertrophy.Biochemistry and biophysics reports · 2019Article
- Molecular Basis for Exercise-Induced Fatigue: The Importance of Strictly Controlled Cellular CaCold Spring Harbor perspectives in medicine · 2018Review
- Activity-induced CaeLife · 2018Article
- Improved Exercise Tolerance with Caffeine Is Associated with Modulation of both Peripheral and Central Neural Processes in Human Participants.Frontiers in nutrition · 2018Article
- Microvascular oxygen pressures in muscles comprised of different fiber types: Impact of dietary nitrate supplementation.Nitric oxide : biology and chemistry · 2015Article
- Sodium selective erythrocyte glycocalyx and salt sensitivity in man.Pflugers Archiv : European journal of physiology · 2015Article
- Fatigue and pacing in high-intensity intermittent team sport: an update.Sports medicine (Auckland, N.Z.) · 2014Review
- Unaccustomed eccentric contractions impair plasma K+ regulation in the absence of changes in muscle Na+,K+-ATPase content.PloS one · 2014Article
- Effects of high-frequency stimulation and doublets on dynamic contractions in rat soleus muscle exposed to normal and high extracellular [K(+)].Physiological reports · 2013Article
- Relationships between resting conductances, excitability, and t-system ionic homeostasis in skeletal muscle.The Journal of general physiology · 2011Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulation of K+ in skeletal muscle interstitium during intense exercise has been suggested to cause fatigue in humans. The present study examined interstitial K+ kinetics and fatigue during repeated, intense, exhaustive exercise in human skeletal muscle. Ten subjects performed three repeated, intense (61.6+/-4.1 W; mean+/-SEM), one-legged knee extension exercise bouts (EX1, EX2 and EX3) to exhaustion separated by 10-min recovery periods. Interstitial [K+] ([K+]interst) in the vastus lateralis muscle were determined using microdialysis. Time-to-fatigue decreased progressively (P<0.05) during the protocol (5.1+/-0.4, 4.2+/-0.3 and 3.2+/-0.2 min for EX1, EX2 and EX3 respectively). Prior to these bouts, [K+]interst was 4.1+/-0.2, 4.8+/-0.2 and 5.2+/-0.2 mM, respectively. During the initial 1.5 min of exercise the accumulation rate of interstitial K+ was 85% greater (P<0.05) in EX1 than in EX3. At exhaustion [K+]interst was 11.4+/-0.8 mM in EX1, which was not different from that in EX2 (10.4+/-0.8 mM), but higher (P<0.05) than in EX3 (9.1+/-0.3 mM). The study demonstrated that the rate of accumulation of K+ in the muscle interstitium declines during intense repetitive exercise. Furthermore, whilst [K+]interst at exhaustion reached levels high enough to impair performance, the concentration decreased with repeated exercise, suggesting that accumulation of interstitial K+ per se does not cause fatigue when intense exercise is repeated.
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