ArticlePflugers Archiv : European journal of physiology2004
Cardiac connexins Cx43 and Cx45: formation of diverse gap junction channels with diverse electrical properties.
Article in Pflugers Archiv : European journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Therapeutic Potential of Exosome for Cardiac Arrhythmia: A Systematic Review of Preclinical Evidence.Stem cell reviews and reports · 2025Pooled it
- Article
- Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate.Cancers · 2021Article
- Effect of Variations in Gap Junctional Coupling on the Frequency of Oscillatory Action Potentials in a Smooth Muscle Syncytium.Frontiers in physiology · 2021Article
- Non-ohmic tissue conduction in cardiac electrophysiology: Upscaling the non-linear voltage-dependent conductance of gap junctions.PLoS computational biology · 2020Article
- Proarrhythmic Electrical Remodeling by Noncardiomyocytes at Interfaces With Cardiomyocytes Under Oxidative Stress.Frontiers in physiology · 2020Article
- Intramolecular signaling in a cardiac connexin: Role of cytoplasmic domain dimerization.Journal of molecular and cellular cardiology · 2017Article
- Cardiac Cx43, Cx40 and Cx45 co-assembling: involvement of connexins epitopes in formation of hemichannels and Gap junction channels.BMC cell biology · 2017Review
- Illuminating Myocyte-Fibroblast Homotypic and Heterotypic Gap Junction Dynamics Using Dynamic Clamp.Biophysical journal · 2016Article
- Computational Approaches to Understanding the Role of Fibroblast-Myocyte Interactions in Cardiac Arrhythmogenesis.BioMed research international · 2015Review
- Computational model of erratic arrhythmias in a cardiac cell network: the role of gap junctions.PloS one · 2014Article
- Characterisation of connexin expression and electrophysiological properties in stable clones of the HL-1 myocyte cell line.PloS one · 2014Article
- Organ explant culture of neonatal rat ventricles: a new model to study gene and cell therapy.PloS one · 2013Article
- Connexin diversity in the heart: insights from transgenic mouse models.Frontiers in pharmacology · 2013Article
- Channeling diversity: gap junction expression in the heart.Heart rhythm · 2012Article
- Electrical coupling and propagation in engineered ventricular myocardium with heterogeneous expression of connexin43.Circulation research · 2012Article
- Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current.Cardiovascular research · 2012Article
- Cell-to-cell coupling in engineered pairs of rat ventricular cardiomyocytes: relation between Cx43 immunofluorescence and intercellular electrical conductance.American journal of physiology. Heart and circulatory physiology · 2012Article
- Influence of v5/6-His tag on the properties of gap junction channels composed of connexin43, connexin40 or connexin45.The Journal of membrane biology · 2011Article
- Gap junctions in olfactory neurons modulate olfactory sensitivity.BMC neuroscience · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HeLa cells expressing rat connexin43 (Cx43) and/or mouse Cx45 were studied with the dual voltage-clamp technique. Different types of cell pairs were established and their gap junction properties determined, i.e. the dependence of the instantaneous and steady-state conductances (gj,inst, gj,ss) on the transjunctional voltage (Vj) and the kinetics of inactivation of the gap junction current (Ij). Pairs of singly transfected cells showed homogeneous behaviour at both Vj polarities. Homotypic Cx43-Cx43 and Cx45-Cx45 cell pairs yielded distinct symmetrical functions gj,inst=f(Vj) and gj,ss=f(Vj). Heterotypic Cx43-Cx45 preparations exhibited asymmetric functions gj,inst=f(Vj) and gj,ss=f(Vj) suggesting that connexons Cx43 and Cx45 gate with positive and negative Vj, respectively. Preparations containing a singly (Cx43 or Cx45) or doubly (Cx43/45) transfected cell showed quasi-homogeneous behaviour at one Vj polarity and heterogeneous behaviour at the other polarity. The former yielded Boltzmann parameters intermediate between those of Cx43-Cx43, Cx45-Cx45 and Cx43-Cx45 preparations; the latter could not be explained by homotypic and heterotypic combinations of homomeric connexons. Each pair of doubly transfected cells (Cx43/Cx45) yielded unique functions gj,inst=f(Vj) and gj,ss=f(Vj). This can not be explained by combinations of homomeric connexons. We conclude that Cx43 and Cx45 form homomeric-homotypic, homomeric-heterotypic channels as well as heteromeric-homotypic and heteromeric-heterotypic channels. This has implications for the impulse propagation in specific areas of the heart.
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