ArticleOncogene2004
Redox regulation of annexin 2 and its implications for oxidative stress-induced renal carcinogenesis and metastasis.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 81 citations in OpenAlex.
- Prognosis of stage II colon cancer by non-neoplastic mucosa gene expression profiling.Oncogene · 2007Trial
- The intricate role of annexin A2 in kidney: a comprehensive review.Renal failure · 2023Review
- Annexin A2 and Kidney Diseases.Frontiers in cell and developmental biology · 2022Review
- Human epididymis protein 4 promotes P‑glycoprotein‑mediated chemoresistance in ovarian cancer cells through interactions with Annexin II.Molecular medicine reports · 2021Article
- Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering.Cancers · 2020Review
- Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of annexin A2.Journal of cell science · 2016Article
- Receptor role of the annexin A2 in the mesothelial endocytosis of crocidolite fibers.Laboratory investigation; a journal of technical methods and pathology · 2015Article
- Structure-function analysis of apical membrane-associated molecules of the tegument of schistosome parasites of humans: prospects for identification of novel targets for parasite control.British journal of pharmacology · 2015Review
- NOX1 supports the metabolic remodeling of HepG2 cells.PloS one · 2015Article
- Human epididymis protein 4 in association with Annexin II promotes invasion and metastasis of ovarian cancer cells.Molecular cancer · 2014Article
- Iron and thiols as two major players in carcinogenesis: friends or foes?Frontiers in pharmacology · 2014Review
- Iron overload as a major targetable pathogenesis of asbestos-induced mesothelial carcinogenesis.Redox report : communications in free radical research · 2014Review
- Prognostic significance of annexin II expression in non-small cell lung cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2013Article
- Annexin A2: the importance of being redox sensitive.International journal of molecular sciences · 2013Article
- Effects of nickel, chlorpyrifos and their mixture on the Dictyostelium discoideum proteome.International journal of molecular sciences · 2012Article
- Annexin A2 silencing induces G2 arrest of non-small cell lung cancer cells through p53-dependent and -independent mechanisms.The Journal of biological chemistry · 2012Article
- Bovine lactoferrin ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats.Journal of clinical biochemistry and nutrition · 2012Article
- Quantitative proteomic analysis identifying three annexins as lymph node metastasis-related proteins in lung adenocarcinoma.Medical oncology (Northwood, London, England) · 2012Article
- Revealing the molecular mechanism of gastric cancer marker annexin A4 in cancer cell proliferation using exon arrays.PloS one · 2012Article
- Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer.PloS one · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ferric nitrilotriacetate (Fe-NTA) induces oxidative renal damage leading to a high incidence of renal cell carcinoma (RCC) in rats. Differential display analysis of such RCCs revealed elevated expression of annexin 2 (Anx2), a substrate for kinases and a receptor for tissue-type plasminogen activator and plasminogen. We conducted this study to clarify the significance of Anx2 in Fenton reaction-based carcinogenesis. Messenger RNA and protein levels of Anx2 were increased time-dependently in the rat kidney after Fe-NTA administration as well as in LLC-PK1 cells after exposure to H2O2. The latter was inhibited by pretreatment with N-acetylcysteine, pyrrolidine dithiocarbamate or catalase. Immunohistochemistry revealed negligible staining in the normal renal proximal tubules, but strong staining in regenerating proximal tubules, karyomegalic cells and RCCs. Metastasizing RCCs showed higher Anx2 protein levels. Anx2 was phosphorylated at serine and tyrosine residues in these cells and coimmunoprecipitated with phosphorylated actin. Overexpression of Anx2 induced a higher cell proliferation rate in LLC-PK1 cells. In contrast, a decrease in proliferation leading to apoptosis was observed after Anx2 antisense treatment to cell lines established from Fe-NTA-induced RCCs. These results suggest that Anx2 is regulated by redox status, and that persistent operation of this adaptive mechanism plays a role in the proliferation and metastasis of oxidative stress-induced cancer.
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