ArticleOncogene2004
Maspin expression in normal lung and non-small-cell lung cancers: cellular property-associated expression under the control of promoter DNA methylation.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- Upregulation of maspin expression in human cervical carcinoma cells by transforming growth factor β1 through the convergence of Smad and non-Smad signaling pathways.Oncology letters · 2017Article
- Decreased maspin combined with elevated vascular endothelial growth factor C is associated with poor prognosis in non-small cell lung cancer.Thoracic cancer · 2014Article
- Role of maspin in cancer.Clinical and translational medicine · 2013Article
- High frequency of coexpression of maspin with p63 and p53 in squamous cell carcinoma but not in adenocarcinoma of the lung.International journal of clinical and experimental pathology · 2013Article
- Maspin and MCM2 immunoprofiling in salivary gland carcinomas.Diagnostic pathology · 2011Article
- DNA Methylation Profiles of Protease Nexin 1 (SERPINE2) Gene in Human Cell Lines.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2011Article
- Reactivation of MASPIN in non-small cell lung carcinoma (NSCLC) cells by artificial transcription factors (ATFs).Epigenetics · 2011Article
- Article
- Maspin regulates endothelial cell adhesion and migration through an integrin signaling pathway.The Journal of biological chemistry · 2010Article
- Epigenetic silencing of maspin expression occurs early in the conversion of keratocytes to fibroblasts.Experimental eye research · 2008Article
- LKB1 gene mutations in Japanese lung cancer patients.Cancer science · 2007Article
- Nuclear and cytoplasmic Maspin expression in primary non-small cell lung cancer.Journal of clinical pathology · 2007Article
- Connections between epigenetic gene silencing and human disease.Mutation research · 2007Review
- Maspin: the new frontier.Clinical cancer research : an official journal of the American Association for Cancer Research · 2006Review
- Aberrant maspin expression in human endometrial cancer.Cancer science · 2006Article
- Clinical relevance of maspin expression in bladder cancer.World journal of urology · 2006Article
- Epigenetic regulation of the cell type-specific gene 14-3-3sigma.Neoplasia (New York, N.Y.) · 2005Article
- Aberrant expression of maspin in idiopathic inflammatory bowel disease is associated with disease activity and neoplastic transformation.International journal of gastrointestinal cancer · 2005Article
- S100A2 is strongly expressed in airway basal cells, preneoplastic bronchial lesions and primary non-small cell lung carcinomas.British journal of cancer · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maspin has been demonstrated to be a suppressor of invasion and cell motility in vitro, whereas in vivo analyses have reported that increased expression of maspin is associated with malignant behavior. The present study examined maspin expression in normal lung and non-small-cell lung cancers. Only proximal airway cells in the normal lung expressed maspin, and the expression was associated with decreased methylation. This association was also observed in non-small-cell lung cancers, but the expression was quite different among histologic subtypes; 20 of 21 squamous cell carcinomas showed intense, uniform expression, whereas the expression status varied among adenocarcinomas. Of the 119 adenocarcinomas, 60 were negative, 23 positive and 36 showed a heterogeneous expression pattern. The expression was inversely correlated with markers of peripheral airway cells. Taken together, the results suggest that maspin may be expressed in association with the proximal airway cell type. It is of note that the heterogeneous expression pattern of maspin is quite distinctive, showing geographic positivity in the individual tumors. Separate analysis of methylation status in positive and negative portions of individual tumors provided an instance of intratumor diversity associated with promoter DNA methylation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.