ArticleThorax2004
Inflammatory features of nasal mucosa in smokers with and without COPD.
Article in Thorax, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 86 citations in OpenAlex.
- From clinical phenotypes to cellular mechanisms: a precision medicine framework for COPD.Frontiers in immunology · 2026Review
- The Effect of Fluticasone Nasal Spray on Patients with Chronic Rhinitis and Chronic Obstructive Pulmonary Disease.Journal of clinical medicine · 2025Article
- Relationships between Airway Remodeling and Clinical Characteristics in COPD Patients.Biomedicines · 2022Article
- Preventing Parkinson's Disease: An Environmental Agenda.Journal of Parkinson's disease · 2022Review
- Expression of long non-coding RNA LUCAT1 in patients with chronic obstructive pulmonary disease and its potential functions in regulating cigarette smoke extract-induced 16HBE cell proliferation and apoptosis.Journal of clinical laboratory analysis · 2021Article
- Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Altered generation of ciliated cells in chronic obstructive pulmonary disease.Scientific reports · 2019Article
- Cigarette smoke affects the onco-suppressor DAB2IP expression in bronchial epithelial cells of COPD patients.Scientific reports · 2019Article
- Asthma, Sinonasal Disease, and the Risk of Active Tuberculosis.The journal of allergy and clinical immunology. In practice · 2019Article
- Airway Epithelium Dysfunction in Cystic Fibrosis and COPD.Mediators of inflammation · 2018Review
- Clinical impact of nasal budesonide treatment on COPD patients with coexistent rhinitis.International journal of chronic obstructive pulmonary disease · 2018Observational
- Underrecognized comorbidities of chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2015Review
- ICON: chronic rhinosinusitis.The World Allergy Organization journal · 2014Article
- Analysis of lower airway inflammation in a rabbit model of acute rhinosinusitis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2011Article
- Cigarette smoking and self-assessed upper airway health.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2011Article
- Different regulation of cigarette smoke induced inflammation in upper versus lower airways.Respiratory research · 2010Article
- Rhinosinusitis in COPD: symptoms, mucosal changes, nasal lavage cells and eicosanoids.International journal of chronic obstructive pulmonary disease · 2010Article
- Reticular basement membrane in asthma and COPD: similar thickness, yet different composition.International journal of chronic obstructive pulmonary disease · 2009Article
- Chronic rhinosinusitis and risk of lung cancer in the Singapore Chinese Health Study.International journal of cancer · 2008Article
- Toll-like receptor-4 mediates cigarette smoke-induced cytokine production by human macrophages.Respiratory research · 2006Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate whether nasal and bronchial inflammation coexists in chronic obstructive pulmonary disease (COPD), nasal and bronchial biopsy specimens from seven control subjects, seven smokers without COPD, and 14 smokers with COPD were studied.
methodsNasal and bronchial biopsy specimens were taken from the same patients during bronchoscopy and squamous cell metaplasia and the thickness of the epithelium and basement membrane were measured. The numbers of eosinophils (EG2), neutrophils (elastase), macrophages (CD68), and CD8 T lymphocytes (CD8/144B) were assessed by immunohistochemistry.
resultsSmokers with and without COPD had squamous metaplasia in the nasal and bronchial epithelium. In all groups the thickness of the nasal epithelium was greater than that of the bronchial epithelium. The thickness of the basement membrane was similar in nasal and bronchial biopsy specimens from smokers with and without COPD, but was greater in the bronchi than in the nasal epithelium of controls. Eosinophil number was higher in the nasal and bronchial mucosa of smokers without COPD than in smokers with COPD or controls. Neutrophil number was higher in the nasal and bronchial mucosa of smokers with COPD than in smokers without COPD or controls. CD8 T lymphocyte numbers were similar in smokers with and without COPD and higher than in controls. There were fewer macrophages in nasal and bronchial biopsy specimens from smokers without COPD than in those with COPD.
conclusionNasal and bronchial inflammation coexists in smokers and is characterised by infiltration of CD8 T lymphocytes. In smokers without COPD this feature is associated with an increased number of eosinophils, while in those with COPD it is linked to an increased number of neutrophils in both nasal and bronchial biopsy specimens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.