ArticleThorax2004
Outbreak of isoniazid resistant tuberculosis in north London.
Article in Thorax, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Ileoscopy in 39 hematochezia patients with normal colonoscopy.World journal of gastroenterology · 2006Trial
- Molecular typing of Mycobacterium tuberculosis: a review of current methods, databases, softwares, and analytical tools.FEMS microbiology reviews · 2025Review
- Transmission analysis of a large tuberculosis outbreak in London: a mathematical modelling study using genomic data.Microbial genomics · 2020Article
- Challenges posed by COVID-19 to people who inject drugs and lessons from other outbreaks.Journal of the International AIDS Society · 2020Article
- Twenty years and counting: epidemiology of an outbreak of isoniazid-resistant tuberculosis in England and Wales, 1995 to 2014.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2017Article
- Isoniazid-resistant tuberculosis: a cause for concern?The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2017Review
- Multiple large clusters of tuberculosis in London: a cross-sectional analysis of molecular and spatial data.ERJ open research · 2017Article
- Tuberculosis in migrants moving from high-incidence to low-incidence countries: a population-based cohort study of 519 955 migrants screened before entry to England, Wales, and Northern Ireland.Lancet (London, England) · 2016Article
- Whole Genome Sequence Analysis of a Large Isoniazid-Resistant Tuberculosis Outbreak in London: A Retrospective Observational Study.PLoS medicine · 2016Observational
- Genetic variation in Mycobacterium tuberculosis isolates from a London outbreak associated with isoniazid resistance.BMC medicine · 2016Article
- Prevalence and correlates of latent tuberculosis infection among employees of a high security prison in Malaysia.Occupational and environmental medicine · 2015Article
- Correlates between models of virulence for Mycobacterium tuberculosis among isolates of the Central Asian lineage: a case for lysozyme resistance testing?Infection and immunity · 2015Article
- Prospective evaluation of a complex public health intervention: lessons from an initial and follow-up cross-sectional survey of the tuberculosis strain typing service in England.BMC public health · 2014Article
- Tuberculosis in UK cities: workload and effectiveness of tuberculosis control programmes.BMC public health · 2011Article
- Article
- Mycobacterium tuberculosis cluster with developing drug resistance, New York, New York, USA, 2003-2009.Emerging infectious diseases · 2011Article
- Genomic stability over 9 years of an isoniazid resistant Mycobacterium tuberculosis outbreak strain in Sweden.PloS one · 2011Article
- Associations between Mycobacterium tuberculosis strains and phenotypes.Emerging infectious diseases · 2010Article
- A Mycobacterium tuberculosis cluster demonstrating the use of genotyping in urban tuberculosis control.BMC infectious diseases · 2009Article
- Mycobacterium tuberculosis ecology in Venezuela: epidemiologic correlates of common spoligotypes and a large clonal cluster defined by MIRU-VNTR-24.BMC infectious diseases · 2009Article
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA description is given of a major outbreak of isoniazid monoresistant tuberculosis (TB) chiefly in north London, including prisons. The earliest case was diagnosed in 1995 with most cases appearing after 1999.
methodsConfirmation of a local cluster of cases was confirmed by restriction fragment length polymorphism (RFLP IS6110) typing or "rapid epidemiological typing" (RAPET). Further cases were found by retrospective analysis of existing databases, prospective screening of new isolates, and targeted epidemiological case detection including questionnaire analysis.
resultsBy the end of 2001, 70 confirmed cases in London had been linked with a further 13 clinical cases in contacts and nine epidemiologically linked cases outside London. The epidemic curve suggests that the peak of the outbreak has not yet been reached. Cases in the outbreak largely belong to a social group of young adults of mixed ethnic backgrounds including several individuals from professional/business backgrounds. Compared with other cases of TB reported to the enhanced surveillance scheme in London during 1999-2001, the cases are more likely to be of white (26/70 (37%) v 1308/7666 (17%)) or black Caribbean ethnicity (17/70 (24%) v 312/7666 (4%)), born in the UK (41/70 (59%) v 1335/7666 (17%)), and male (52/70 (74%) v 4195/7666 (55%)). Drug misuse and/or prison detention are factors common to many cases.
conclusionsThe investigation of the outbreak revealed significant problems on an individual patient and population based level including difficulties with contact tracing, compliance, and the risk of developing multidrug resistance. This incident has demonstrated the value of molecular strain typing in investigating an extensive outbreak of TB. This is the first documented outbreak involving a UK prison.
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