ArticleMolecular biology of the cell2004
Cytoplasmic dynein nucleates microtubules to organize them into radial arrays in vivo.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Branched microtubule nucleation and dynein transport organize RanGTP asters inMolecular biology of the cell · 2024Article
- Article
- The Light Intermediate Chain 2 Subpopulation of Dynein Regulates Mitotic Spindle Orientation.Scientific reports · 2016Article
- Ndel1 and Reelin Maintain Postnatal CA1 Hippocampus Integrity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Engineered Tug-of-War Between Kinesin and Dynein Controls Direction of Microtubule Based Transport In Vivo.Traffic (Copenhagen, Denmark) · 2016Article
- Translocating myonuclei have distinct leading and lagging edges that require kinesin and dynein.Development (Cambridge, England) · 2014Article
- Golgi as an MTOC: making microtubules for its own good.Histochemistry and cell biology · 2013Review
- Let's huddle to prevent a muddle: centrosome declustering as an attractive anticancer strategy.Cell death and differentiation · 2012Review
- Neuronal polarity: demarcation, growth and commitment.Current opinion in cell biology · 2012Review
- Genetic interaction of centrosomin and bazooka in apical domain regulation in Drosophila photoreceptor.PloS one · 2011Article
- Quantification of asymmetric microtubule nucleation at subcellular structures.Methods in molecular biology (Clifton, N.J.) · 2011Article
- Self-organization in systems of treadmilling filaments.The European physical journal. E, Soft matter · 2010Article
- Microtubule network asymmetry in motile cells: role of Golgi-derived array.Cell cycle (Georgetown, Tex.) · 2009Review
- Anterograde microtubule transport drives microtubule bending in LLC-PK1 epithelial cells.Molecular biology of the cell · 2009Article
- Specificity of cytoplasmic dynein subunits in discrete membrane-trafficking steps.Molecular biology of the cell · 2009Article
- A multicomponent assembly pathway contributes to the formation of acentrosomal microtubule arrays in interphase Drosophila cells.Molecular biology of the cell · 2008Article
- Ste20-related protein kinase LOSK (SLK) controls microtubule radial array in interphase.Molecular biology of the cell · 2008Article
- Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network.Developmental cell · 2007Article
- Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly.Molecular biology of the cell · 2006Article
- Self-organization of an acentrosomal microtubule network at the basal cortex of polarized epithelial cells.The Journal of cell biology · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Numerous evidence demonstrates that dynein is crucial for organization of microtubules (MTs) into radial arrays, but its exact function in this process is unclear. Here, we studied the role of cytoplasmic dynein in MT radial array formation in the absence of the centrosome. We found that dynein is a potent MT nucleator in vitro and that stimulation of dynein activity in cytoplasmic fragments of melanophores induces nucleation-dependent formation of MT radial array in the absence of the centrosome. This new property of dynein, in combination with its known role as an MT motor that is essential for MT array organization in the absence and presence of the centrosome, makes it a unique molecule whose activity is necessary and sufficient for the formation and maintenance of MT radial arrays in cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.