ArticleMolecular biology of the cell2004
The Sec1/Munc18 protein, Vps33p, functions at the endosome and the vacuole of Saccharomyces cerevisiae.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 61 citations in OpenAlex.
- Neuronal SNARE complex assembly guided by Munc18-1 and Munc13-1.FEBS open bio · 2022Review
- Better Together: Current Insights Into Phagosome-Lysosome Fusion.Frontiers in immunology · 2021Review
- The Secret Life of Tethers: The Role of Tethering Factors in SNARE Complex Regulation.Frontiers in cell and developmental biology · 2016Review
- Membrane Tethering Complexes in the Endosomal System.Frontiers in cell and developmental biology · 2016Review
- Function and regulation of the endosomal fusion and fission machineries.Cold Spring Harbor perspectives in biology · 2014Review
- The effect of natamycin on the transcriptome of conidia of Aspergillus niger.Studies in mycology · 2013Article
- Functional separation of endosomal fusion factors and the class C core vacuole/endosome tethering (CORVET) complex in endosome biogenesis.The Journal of biological chemistry · 2013Article
- Sec1/Munc18 protein Vps33 binds to SNARE domains and the quaternary SNARE complex.Molecular biology of the cell · 2012Article
- The role of Munc18-1 and its orthologs in modulation of cortical F-actin in chromaffin cells.Journal of molecular neuroscience : MN · 2012Review
- Aspergillus RabB Rab5 integrates acquisition of degradative identity with the long distance movement of early endosomes.Molecular biology of the cell · 2010Article
- Mapping of Vps21 and HOPS binding sites in Vps8 and effect of binding site mutants on endocytic trafficking.Eukaryotic cell · 2010Article
- Transcriptional responses of candida albicans to epithelial and endothelial cells.Eukaryotic cell · 2009Article
- Vps-C complexes: gatekeepers of endolysosomal traffic.Current opinion in cell biology · 2009Review
- Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing.The EMBO journal · 2009Article
- The SM protein Car/Vps33A regulates SNARE-mediated trafficking to lysosomes and lysosome-related organelles.Molecular biology of the cell · 2009Article
- SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery.Molecular biology of the cell · 2009Article
- A novel immunodetection screen for vacuolar defects identifies a unique allele of VPS35 in S. cerevisiae.Molecular and cellular biochemistry · 2008Article
- Yarrowia lipolytica vesicle-mediated protein transport pathways.BMC evolutionary biology · 2007Article
- Rabs and their effectors: achieving specificity in membrane traffic.Proceedings of the National Academy of Sciences of the United States of America · 2006Review
- The clathrin adaptor complex 1 directly binds to a sorting signal in Ste13p to reduce the rate of its trafficking to the late endosome of yeast.The Journal of cell biology · 2006Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Sec1/Munc18 (SM) family of proteins is thought to impart compartmental specificity to vesicle fusion reactions. Here we report characterization of Vps33p, an SM family member previously thought to act exclusively at the vacuolar membrane with the vacuolar syntaxin Vam3p. Vacuolar morphology of vps33Delta cells resembles that of cells lacking both Vam3p and the endosomal syntaxin Pep12p, suggesting that Vps33p may function with these syntaxins at the vacuole and the endosome. Consistent with this, vps33 mutants secrete the Golgi precursor form of the vacuolar hydrolase CPY into the medium. We also demonstrate that Vps33p acts at other steps, for vps33 mutants show severe defects in endocytosis at the late endosome. At the endosome, Vps33p and other class C members exist as a complex with Vps8p, a protein previously known to act in transport between the late Golgi and the endosome. Vps33p also interacts with Pep12p, a known interactor of the SM protein Vps45p. High copy PEP7/VAC1 suppresses vacuolar morphology defects of vps33 mutants. These findings demonstrate that Vps33p functions at multiple trafficking steps and is not limited to action at the vacuolar membrane. This is the first report demonstrating the involvement of a single syntaxin with two SM proteins at the same organelle.
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