ArticleJournal of virology2004
Rubella virus capsid protein modulates viral genome replication and virus infectivity.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Exogenous Rubella Virus Capsid Proteins Enhance Virus Genome Replication.Pathogens (Basel, Switzerland) · 2022Article
- Epidemiological analysis of rubella-confirmed cases from measles suspected cases in Ethiopia: Threat for Congenital Rubella Syndrome.Epidemiology and infection · 2022Article
- Infectious vaccine-derived rubella viruses emerge, persist, and evolve in cutaneous granulomas of children with primary immunodeficiencies.PLoS pathogens · 2019Article
- Cotranslational coat protein-mediated inhibition of potyviral RNA translation.Journal of virology · 2015Article
- Short self-interacting N-terminal region of rubella virus capsid protein is essential for cooperative actions of capsid and nonstructural p150 proteins.Journal of virology · 2014Article
- The classic swine fever virus (CSFV) core protein can enhance de novo-initiated RNA synthesis by the CSFV polymerase NS5B.Virus genes · 2014Article
- Rubella virus capsid protein structure and its role in virus assembly and infection.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Review
- Norovirus RNA synthesis is modulated by an interaction between the viral RNA-dependent RNA polymerase and the major capsid protein, VP1.Journal of virology · 2012Article
- The rubella virus capsid protein inhibits mitochondrial import.Journal of virology · 2010Article
- Regulation of hepatitis C virus replication by the core protein through its interaction with viral RNA polymerase.Biochemical and biophysical research communications · 2009Article
- Characteristics of Nipah virus and Hendra virus replication in different cell lines and their suitability for antiviral screening.Virus research · 2009Article
- Functional replacement of a domain in the rubella virus p150 replicase protein by the virus capsid protein.Journal of virology · 2009Article
- Rubella virus capsid protein interacts with poly(a)-binding protein and inhibits translation.Journal of virology · 2008Article
- Comparison of four methods using throat swabs to confirm rubella virus infection.Journal of clinical microbiology · 2007Article
- Novel replication complex architecture in rubella replicon-transfected cells.Cellular microbiology · 2007Article
- Analyses of phosphorylation events in the rubella virus capsid protein: role in early replication events.Journal of virology · 2006Article
- Analysis of rubella virus capsid protein-mediated enhancement of replicon replication and mutant rescue.Journal of virology · 2006Article
- Interactions between rubella virus capsid and host protein p32 are important for virus replication.Journal of virology · 2005Article
- Coat protein activation of alfalfa mosaic virus replication is concentration dependent.Journal of virology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The structural proteins (SP) of the Togaviridae can be deleted in defective interfering RNAs. The dispensability of viral SP has allowed construction of noninfectious viral expression vectors and replicons from viruses of the Alphavirus and Rubivirus genera. Nevertheless, in this study, we found that the SP of rubella virus (RUB) could enhance expression of reporter genes from RUB replicons in trans. SP enhancement required capsid protein (CP) expression and was not due to RNA-RNA recombination. Accumulation of minus- and plus-strand RNAs from replicons was observed in the presence of SP, suggesting that SP specifically affects RNA synthesis. By using replicons containing an antibiotic resistance gene, we found 2- to 50-fold increases in the number of cells surviving selection in the presence of SP. The increases depended significantly on the amount of transfected RNA. Small amounts of RNA or templates that replicated inefficiently showed more enhancement. The infectivity of infectious RNA was increased by at least 10-fold in cells expressing CP. Moreover, virus infectivity was greatly enhanced in such cells. In other cells that expressed higher levels of CP, RNA replication of replicons was inhibited. Thus, depending on conditions, CP can markedly enhance or inhibit RUB RNA replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.