ArticleJournal of virology2004
tRNA-like structure regulates translation of Brome mosaic virus RNA.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- A new level of RNA-based plant protection: dsRNAs designed from functionally characterized siRNAs highly effective against Cucumber mosaic virus.Nucleic acids research · 2025Article
- Structural insights into dynamics of the BMV TLS aminoacylation.Nature communications · 2025Article
- Non-Canonical Translation Initiation Mechanisms Employed by Eukaryotic Viral mRNAs.Biochemistry. Biokhimiia · 2021Review
- An expanded class of histidine-accepting viral tRNA-like structures.RNA (New York, N.Y.) · 2021Article
- Article
- Identification of Long-Distance Transmissible mRNA between Scion and Rootstock in Cucurbit Seedling Heterografts.International journal of molecular sciences · 2020Article
- Ribosome-induced RNA conformational changes in a viral 3'-UTR sense and regulate translation levels.Nature communications · 2018Article
- PlaMoM: a comprehensive database compiles plant mobile macromolecules.Nucleic acids research · 2017Article
- Non-canonical Translation in Plant RNA Viruses.Frontiers in plant science · 2017Review
- tRNA-Related Sequences Trigger Systemic mRNA Transport in Plants.The Plant cell · 2016Article
- Exploiting tRNAs to Boost Virulence.Life (Basel, Switzerland) · 2016Review
- Dissecting virus-plant interactions through proteomics approaches.Current proteomics · 2010Article
- LSm1-7 complexes bind to specific sites in viral RNA genomes and regulate their translation and replication.RNA (New York, N.Y.) · 2010Article
- Role of tRNA-like structures in controlling plant virus replication.Virus research · 2009Review
- RNA-binding proteins that inhibit RNA virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Selective repression of translation by the brome mosaic virus 1a RNA replication protein.Journal of virology · 2007Article
- Cap- and initiator tRNA-dependent initiation of TYMV polyprotein synthesis by ribosomes: evaluation of the Trojan horse model for TYMV RNA translation.RNA (New York, N.Y.) · 2007Article
- Translational control in positive strand RNA plant viruses.Virology · 2006Review
- Plant virus RNAs. Coordinated recruitment of conserved host functions by (+) ssRNA viruses during early infection events.Plant physiology · 2005Review
- Repair of the tRNA-like CCA sequence in a multipartite positive-strand RNA virus.Journal of virology · 2005Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For various groups of plant viruses, the genomic RNAs end with a tRNA-like structure (TLS) instead of the 3' poly(A) tail of common mRNAs. The actual function of these TLSs has long been enigmatic. Recently, however, it became clear that for turnip yellow mosaic virus, a tymovirus, the valylated TLS(TYMV) of the single genomic RNA functions as a bait for host ribosomes and directs them to the internal initiation site of translation (with N-terminal valine) of the second open reading frame for the polyprotein. This discovery prompted us to investigate whether the much larger TLSs of a different genus of viruses have a comparable function in translation. Brome mosaic virus (BMV), a bromovirus, has a tripartite RNA genome with a subgenomic RNA4 for coat protein expression. All four RNAs carry a highly conserved and bulky 3' TLS(BMV) (about 200 nucleotides) with determinants for tyrosylation. We discovered TLS(BMV)-catalyzed self-tyrosylation of the tyrosyl-tRNA synthetase but could not clearly detect tyrosine incorporation into any virus-encoded protein. We established that BMV proteins do not need TLS(BMV) tyrosylation for their initiation. However, disruption of the TLSs strongly reduced the translation of genomic RNA1, RNA2, and less strongly, RNA3, whereas coat protein expression from RNA4 remained unaffected. This aberrant translation could be partially restored by providing the TLS(BMV) in trans. Intriguingly, a subdomain of the TLS(BMV) could even almost fully restore translation to the original pattern. We discuss here a model with a central and dominant role for the TLS(BMV) during the BMV infection cycle.
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