ArticleThe Journal of physiology2004
Electrophysiological properties of BK channels in Xenopus motor nerve terminals.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Regulation of Neurotransmitter Release by KAdvances in neurobiology · 2023Article
- Excitatory and inhibitory neural dynamics jointly tune motion detection.Current biology : CB · 2022Article
- Calcium-activated BKThe Journal of physiology · 2017Article
- Concise Whole-Cell Modeling of BKBiophysical journal · 2017Article
- Transient BK outward current enhances motoneurone firing rates during Drosophila larval locomotion.The Journal of physiology · 2015Article
- Archaerhodopsin voltage imaging: synaptic calcium and BK channels stabilize action potential repolarization at the Drosophila neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The contribution of RCK domains to human BK channel allosteric activation.The Journal of biological chemistry · 2012Article
- Function and mechanism of axonal targeting of voltage-sensitive potassium channels.Progress in neurobiology · 2011Review
- Functional apical large conductance, Ca2+-activated, and voltage-dependent K+ channels are required for maintenance of airway surface liquid volume.The Journal of biological chemistry · 2011Article
- Ion channels and signaling in the pituitary gland.Endocrine reviews · 2010Review
- Depolarization-induced Ca2+ entry preferentially evokes release of large quanta in the developing Xenopus neuromuscular junction.Journal of neurophysiology · 2010Article
- Regulation of synaptic transmission by presynaptic CaMKII and BK channels.Molecular neurobiology · 2008Review
- Modulation of Ca(2+)-activated K+ currents and Ca(2+)-dependent action potentials by exocytosis in goldfish bipolar cell terminals.The Journal of physiology · 2006Article
- Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels.The Journal of general physiology · 2006Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single channel properties of Ca(2+)-activated K(+) (BK or Maxi-K) channels have been investigated in presynaptic membranes in Xenopus motoneurone-muscle cell cultures. The occurrence and density of BK channels increased with maturation/synaptogenesis and was not uniform: highest at the release face of bouton-like synaptic varicosities in contact with muscle cells, and lowest in varicosities that did not contact muscle cells. The Ca(2+) affinity of the channel (K(d)= 7.7 microM at a membrane potential of +20 mV) was lower than those of BK channels that have been characterized in other terminals. Hill coefficients varied between 1.5 and 2.8 at different potentials and open probability increased e-fold per 16 mV change in membrane potential over a range of [Ca(2+)](i) from 1 microM to 1 mM. The maximal activation rate of ensembled single BK channel currents was in the submillisecond range at > or =+20 mV. The activation rate increased approximately 10-fold in response to a [Ca(2+)](i) increase from 1 to 100 microM, but increased only approximately 2-fold with a voltage change from +20 to +130 mV. The fastest activation kinetics of BK channels in cell-attached patches resembled that in inside-out patches with [Ca(2+)](i) of 100 microM or more, suggesting that many BK channels are located very close to calcium channels. Given the low Ca(2+) affinity and rapid Ca(2+) binding/unbinding properties, we conclude that BK channels in this preparation are adapted to play an important role in regulation of neurotransmitter release, and they are ideal reporters of local [Ca(2+)] at the inner membrane surface.
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