ArticleAntimicrobial agents and chemotherapy2004
First-choice antibiotics at subinhibitory concentrations induce persistence of Chlamydia pneumoniae.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 63 citations in OpenAlex.
- Review
- Article
- Inhibitory Activity of Pyrroloisoxazolidine Derivatives againstBioMed research international · 2021Article
- Impact of First-Line Antimicrobials onFrontiers in microbiology · 2021Article
- Pyocyanin Inhibits Chlamydia Infection by Disabling Infectivity of the Elementary Body and Disrupting Intracellular Growth.Antimicrobial agents and chemotherapy · 2018Article
- Triclosan Enhances the Clearing of Pathogenic IntracellularFrontiers in cellular and infection microbiology · 2018Article
- Chlamydia trachomatis: the Persistent Pathogen.Clinical and vaccine immunology : CVI · 2017Review
- Persistent C. pneumoniae infection in atherosclerotic lesions: rethinking the clinical trials.Frontiers in cellular and infection microbiology · 2014Review
- What's in a word: the use, misuse, and abuse of the word "persistence" in Chlamydia biology.Frontiers in cellular and infection microbiology · 2014Article
- Commonly prescribed β-lactam antibiotics induce C. trachomatis persistence/stress in culture at physiologically relevant concentrations.Frontiers in cellular and infection microbiology · 2014Article
- Impact of a low-oxygen environment on the efficacy of antimicrobials against intracellular Chlamydia trachomatis.Antimicrobial agents and chemotherapy · 2011Article
- Chlamydia pneumoniae infection and Alzheimer's disease: a connection to remember?Medical microbiology and immunology · 2010Review
- Chlamydophila pneumoniae Infection and Its Role in Neurological Disorders.Interdisciplinary perspectives on infectious diseases · 2010Article
- A novel inhibitor of Chlamydophila pneumoniae protein kinase D (PknD) inhibits phosphorylation of CdsD and suppresses bacterial replication.BMC microbiology · 2009Article
- Association of Chlamydia pneumoniae infection with HLA-B*35 in patients with coronary artery disease.Clinical and vaccine immunology : CVI · 2008Article
- Severe tryptophan starvation blocks onset of conventional persistence and reduces reactivation of Chlamydia trachomatis.Infection and immunity · 2007Article
- Host cell responses to Chlamydia pneumoniae in gamma interferon-induced persistence overlap those of productive infection and are linked to genes involved in apoptosis, cell cycle, and metabolism.Infection and immunity · 2007Article
- Frequency of spontaneous mutations that confer antibiotic resistance in Chlamydia spp.Antimicrobial agents and chemotherapy · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent growth forms of Chlamydia pneumoniae have been associated with chronic infections in vivo. We investigated the effects of first-line therapeutics on the induction of persistence by monitoring recoverable organisms, gene expression of membrane proteins, and morphology. We found that all of the antibiotics tested have distinct and subinhibitory concentrations at which they induce persistence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.